Skeletal endocrine signalling in the regulation of glucose metabolism

骨骼内分泌信号在葡萄糖代谢调节中的作用

• 批准号: DP160100454
• 负责人: Prof Andrew Zannettino
• 金额: $ 26.59万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-05-02 至 2019-05-01
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP160100454
• 关键词: Skeletal; endocrine; signalling; regulation; glucose

This project seeks to explore a highly novel and interesting recent development in bone biology: the fact that the skeleton is a central regulator of glucose metabolism. Currently, the mechanisms involved in this process remain unclear. mTORC1 has been identified as a signalling pathway in bone cells that modulates glucose metabolism. This project plans to selectively delete mTORC1 in the bone cells of mice to examine how skeletal mTORC1 signalling regulates glucose metabolism, and identify novel pathways and circulating factors involved in this process. These studies may provide greater understanding of the basic biology of glucose metabolism, and may have applications in animal husbandry and the future management of diabetes.

该项目旨在探索骨骼生物学领域一个非常新颖且有趣的最新发展：骨骼是葡萄糖代谢的核心调节器这一事实。目前，这一过程所涉及的机制尚不清楚。mTORC1已被鉴定为骨细胞中调节葡萄糖代谢的信号通路。该项目计划选择性地删除小鼠骨细胞中的mTORC 1，以研究骨骼mTORC 1信号如何调节葡萄糖代谢，并确定参与这一过程的新途径和循环因子。这些研究可以提供对葡萄糖代谢的基础生物学的更深入的理解，并且可能在畜牧业和未来的糖尿病管理中具有应用。