National Primate Research Center

此赠款提交，要求5年的资金支持，以继续运作的华盛顿 华盛顿大学国家灵长类动物研究中心。这笔赠款的主要目标是 建议是支持一个基础广泛的研究资源计划，为生物医学科学家提供 利用非人灵长类动物（NHP）模型进行人类健康相关和NHP研究的机会 生物问题。这一目标将通过支持科学知识资源、行政管理、 动物支持资源、设施和操作。需要翻译和临床前支持 艾滋病相关研究、神经科学、功能基因组学和传染病方面的资源支持， 发育和生殖生物学，以及国际计划（研究核心）。新的研究 资源倡议将开发新的NHP模型以及扩大相关的研究资源， 包括新的核心科学家。要求支持试点和群体健康相关研究， 提供新的，创新的研究方向和更好的表征NHP资源。WaNPRC 将专注于有效、高效地获取中心的研究资源，特别强调 支持附属研究活动。该提案还包括支持广泛的动物保护计划。 饲养、饲养和研究活动的护理和技术支持（研究资源部）， 包括国内和国际操作场所。还要求提供行政支助， 确保中心财务和运营的适当管理，重点是提高效率， 为研究活动提供有效支持。要求对位于下列地点的WaNPRC繁殖群体提供支助： 西雅图，杜兰NPRC，新伊比利亚研究中心，以及国际上在印度尼西亚的廷吉尔岛。 在WaNPRC设施中饲养的所有灵长类动物的饲养和照顾条件达到或超过 实验动物护理和使用指南中规定的NIH标准，实验室研究所 动物资源（ILAR）的建议，以及评估和认证协会， NHP的国际实验室动物护理（AAALAC）认证标准。所有慢病毒感染者 将灵长类动物圈养在具有适当生物安全程序的ABSL 2/3封闭设施中。大学 包括WaNPRC在内的华盛顿的所有机构都得到了AAALAC国际的充分认可。

This grant is submitted, requesting 5 years of funding support for continuing operation of the Washington National Primate Research Center at the University of Washington (WaNPRC). The major goal of this grant proposal is to support a broad-based research resources program, providing biomedical scientists the opportunity to conduct research using nonhuman primate (NHP) models for human health-related and NHP biologic issues. This goal will be attained through support for scientific intellectual resources, administration, animal support resources, facilities, and operations. Support is requested for translational and pre-clinical resource support in AIDS-related research, Neuroscience, Functional Genomics and Infectious Disease, Developmental and Reproductive Biology, and International Programs (Research Cores). New research resource initiatives will develop novel NHP models as well as expanded related research resources, including additional new core scientists. Support for pilot and colony health-related studies is requested to provide new, innovative research directions and better characterization of the NHP resource. The WaNPRC will focus on effective, efficient access to Center research resources, with particular emphasis placed on support for affiliate research activities. This proposal also includes support for a broad program of animal care and technical support for breeding, housing, and research activities (Research Resources Division), including both domestic and international sites of operation. Administrative support is also requested to insure appropriate management of Center finances and operations, focusing on improved efficiency and effective support for research activities. Support is requested for WaNPRC breeding colonies located in Seattle, the Tulane NPRC, the New Iberia Research Center, and internationally in Tinjil Island, Indonesia. All primates housed in WaNPRC facilities are housed and cared for under conditions that meet or exceed NIH standards as stated in the Guide for the Care and Use of Laboratory Animals, Institute for Laboratory Animal Resources (ILAR) recommendations, and the Association for Assessment and Accreditation of Laboratory Animal Care, International (AAALAC) accreditation standards for NHPs. All lentivirus-infected primates are housed in ABSL2/3 containment facilities with appropriate biosafety procedures. The University of Washington, including the WaNPRC, is fully accredited by AAALAC International.