State-of-the-art housing to expand the Emory National Primate Research Center SPF rhesus macaque breeding colony

最先进的住房用于扩大埃默里国家灵长类研究中心 SPF 恒河猴繁殖群

• 批准号: 10795471
• 负责人: Joyce Kimberly Cohen
• 金额: $ 799.61万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-06 至 2028-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10795471
• 关键词: Address; Animal Housing; Animal Welfare; Animals; Breeding; Genetic; Housing; Human Resources; Macaca mulatta; Primates; Program Research Project Grants; Research; Research Personnel; Running; design; improved; nonhuman primate; novel; social group

Abstract The robust nonhuman primate research portfolio at the Emory National Primate Research Center (ENPRC), which reached $36.8M in FY2022, has placed significant and unsustainable demands on the Emory NPRC rhesus macaque SPF breeding colony. To meet the current and projected future research demand, ENPRC is proposing to build new animal housing at the ENPRC Field Station to facilitate expansion of the SPF breeding colony. The new animal housing proposed will be a novel housing design that integrates traditional large indoor/ outdoor breeding spaces into a building that includes smaller run housing space as well as animal support space. The run housing will be comprised of traditional indoor run space with accompanying enlarged outdoor run space to facilitate larger social groupings. This combination of compound and run space will maximize breeding potential and facilitate targeted genetic breeding in run groups to support specific research requests and enable colony management needs. The new building will enhance animal welfare with natural substrate in the runs as well as the outdoor compound and include functional features incorporated into the design that will improve animal handling and increase efficiency for personnel. The proposed new animal housing at the Field Station will allow for significant expansion of the SPF rhesus macaque colony over the next five years, thus providing additional animals to support the current research and projected research program for investigators at Emory NPRC as well as for external collaborators to address the nationwide shortage of NHPs for research.

摘要 埃默里国家灵长类研究中心的强大的非人灵长类研究档案 ENPRC(ENPRC)在2022财年达到3680万美元，已经将大量和不可持续的 对埃默里NPRC恒河猴SPF繁殖群体的要求。迎接潮流和挑战 预计未来的研究需求，ENPRC建议在 ENPRC野战站，以促进SPF繁殖群体的扩大。新的动物 拟建的住宅将是一种将传统的大室内/室外相结合的新型住宅设计 将饲养空间改造成包括较小的跑道空间和动物的建筑 支撑空间。跑道外壳将由传统的室内跑道空间组成， 伴随着更大的户外跑步空间，以方便更大的社交团体。这 复合体和运行空间的结合将最大限度地发挥繁殖潜力，并促进定向 在Run群体中进行遗传育种，以支持特定的研究要求并实现群体 管理需求。新建筑将增强动物福利，采用自然基材 跑道和室外大院一样好，并包括融入 设计将改善动物处理并提高工作人员的效率。建议数 野战站的新动物住房将允许SPF恒河猴的显著扩展 未来五年的猕猴种群，从而提供更多的动物来支持 针对Emory NPRC调查人员的当前研究和计划研究计划以及 供外部合作者解决全国范围内用于研究的国家卫生政策短缺问题。