National Primate Research Center

提交这笔赠款，要求为华盛顿继续运营提供5年的资金支持 华盛顿大学国家灵长类研究中心(WaNPRC)。这笔赠款的主要目标是 建议支持一个基础广泛的研究资源计划，为生物医学科学家提供 利用与人类健康相关的非人灵长类(NHP)模型进行研究的机会 生物问题。这一目标将通过支持科学智力资源、行政管理、 动物支持资源、设施和操作。要求为转换和临床前提供支持 艾滋病相关研究、神经科学、功能基因组学和传染病方面的资源支持， 发育与生殖生物学和国际项目(研究核心)。新研究 资源倡议将开发新的国家惠普模式以及扩大相关研究资源， 包括额外的新核心科学家。要求为飞行员和群体健康相关研究提供支持 提供新的、创新的研究方向，并更好地描述国家热泵资源。WANPRC 将侧重于有效、高效地获取中心研究资源，特别强调 支持附属研究活动。这项提案还包括支持广泛的动物保护计划。 为养殖、住房和研究活动提供关怀和技术支持(研究资源司)， 包括国内和国际两个运营地点。还要求提供行政支持以 确保对中心财务和运营进行适当的管理，重点是提高效率和 对研究活动的有效支持。请求支持位于以下地点的WaNPRC繁殖群体 西雅图、杜兰NPRC、新伊比利亚研究中心，以及印度尼西亚廷吉尔岛的国际研究中心。 所有居住在WaNPRC设施中的灵长类动物都是在符合或超过条件的情况下居住和照顾的 美国国立卫生研究院实验动物护理和使用指南中所述的标准 动物资源(ILAR)建议，以及动物资源评估和认证协会 国际实验动物保护协会(AAALAC)对NHP的认可标准。所有慢病毒感染 灵长类动物被安置在ABSL2/3隔离设施中，并配有适当的生物安全程序。这所大学 华盛顿大学，包括WANPRC，都得到了AAALAC国际的完全认可。

This grant is submitted, requesting 5 years of funding support for continuing operation of the Washington National Primate Research Center at the University of Washington (WaNPRC). The major goal of this grant proposal is to support a broad-based research resources program, providing biomedical scientists the opportunity to conduct research using nonhuman primate (NHP) models for human health-related and NHP biologic issues. This goal will be attained through support for scientific intellectual resources, administration, animal support resources, facilities, and operations. Support is requested for translational and pre-clinical resource support in AIDS-related research, Neuroscience, Functional Genomics and Infectious Disease, Developmental and Reproductive Biology, and International Programs (Research Cores). New research resource initiatives will develop novel NHP models as well as expanded related research resources, including additional new core scientists. Support for pilot and colony health-related studies is requested to provide new, innovative research directions and better characterization of the NHP resource. The WaNPRC will focus on effective, efficient access to Center research resources, with particular emphasis placed on support for affiliate research activities. This proposal also includes support for a broad program of animal care and technical support for breeding, housing, and research activities (Research Resources Division), including both domestic and international sites of operation. Administrative support is also requested to insure appropriate management of Center finances and operations, focusing on improved efficiency and effective support for research activities. Support is requested for WaNPRC breeding colonies located in Seattle, the Tulane NPRC, the New Iberia Research Center, and internationally in Tinjil Island, Indonesia. All primates housed in WaNPRC facilities are housed and cared for under conditions that meet or exceed NIH standards as stated in the Guide for the Care and Use of Laboratory Animals, Institute for Laboratory Animal Resources (ILAR) recommendations, and the Association for Assessment and Accreditation of Laboratory Animal Care, International (AAALAC) accreditation standards for NHPs. All lentivirus-infected primates are housed in ABSL2/3 containment facilities with appropriate biosafety procedures. The University of Washington, including the WaNPRC, is fully accredited by AAALAC International.