Neural Basis of Self-Motion Perception

自我运动感知的神经基础

• 批准号: 7582263
• 负责人: Dora Angelaki
• 金额: $ 38万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-02-01 至 2012-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7582263
• 关键词: Address; Anterior; Area; Arts; Behavioral; Bilateral; Cognitive; Cognitive deficits; Complex; Cues; Darkness; Discrimination; Dorsal; Environment; Eye; Goals; Hand; Head; Illusions; Image; Individual; Knowledge; Lateral; Link; Macaca mulatta; Medial; Monkeys; Motion; Motion Perception; Neurons; Oral cavity; Pattern; Perception; Performance; Population; Positioning Attribute; Process; Property; Relative (related person); Retina; Retinal; Rotation; Self Perception; Sensory; Signal Transduction; Somatosensory Cortex; Space Perception; Stimulus; Temporal Lobe; Testing; Translations; Visual; Visual Cortex; Work; base; cognitive neuroscience; eye center; intraparietal sulcus; labyrinthectomy; multisensory; optic flow; preference; relating to nervous system; research study; response; sample fixation; sensory integration; somatosensory; ventral intraparietal area; virtual reality; visual information; visual optics; visual-vestibular

DESCRIPTION (provided by applicant): To navigate effectively through a complex three-dimensional environment, we must accurately estimate our own motion relative to the objects around us. Perception of self-motion is a multi-modal process, involving integration of visual, vestibular, and proprioceptive/somatosensory cues. For example, patterns of image motion across the retina ('optic flow') can be strong cues to self-motion, as evidenced by the fact that optic flow alone can elicit the illusion of self-motion (vection). We propose here to systematically explore a potential contribution of area 2v in the perception of translational and/or rotational self-motion and to directly compare these contributions to those of the ventral intraparietal area (VIP) and the dorsal subdivision of the medial superior temporal (MSTd) areas. Area 2v is one of the so-called 'vestibular' cortical areas with both vestibular and optic flow responsiveness, located in the most anterior and lateral tip of the intraparietal sulcus. Simultaneous behavioral and electrophysiological experiments will be carried out using rhesus monkeys in a state-of-the-art virtual reality apparatus. These studies will combine behavioral, cognitive, and neural analyses to address an important, yet underdeveloped, area of sensory and cognitive neuroscience: the mechanisms of multi-sensory integration underlying self-motion perception. We will be attacking this difficult problem using a combination of `. Specific aims 1 and 2 will characterize the 3D tuning properties of neurons during optic flow stimulation alone (Visual condition), motion in darkness (Vestibular condition) and Combined combinations of the two cues. In addition, we will also characterize the reference frames of Visual or Vestibular signals. In aim 3, we will test for direct links between area 2v neuronal activity and self-motion perception using a fine motion direction discrimination task. Together, these studies will provide a vital test of the hypothesis that area 2v is part of the neural substrate for self-motion perception. The proposed studies aim at filling an apparent gap in knowledge, important for understanding and treating cognitive deficits of spatial perception.

描述（由申请人提供）：为了在复杂的三维环境中有效导航，我们必须准确地估计我们自己相对于周围物体的运动。自我运动的感知是一个多模态的过程，涉及视觉、前庭和本体感觉/躯体感觉线索的整合。例如，视网膜上的图像运动模式（“光流”）可以是自我运动的强烈线索，这一事实证明，光流本身就可以引起自我运动的错觉（vection）。在这里，我们建议系统地探讨潜在的贡献区2 V的平移和/或旋转的自我运动的看法，并直接比较这些贡献的腹侧顶内区（VIP）和背侧细分内侧上级颞（MSTd）地区。2 v区是所谓的“前庭”皮质区之一，具有前庭和视流反应性，位于顶内沟的最前部和外侧尖端。同时进行的行为和电生理实验将使用恒河猴在一个国家的最先进的虚拟现实设备。这些研究将结合联合收割机的行为，认知和神经分析，以解决一个重要的，但欠发达的，区域的感觉和认知神经科学：机制的多感觉整合自我运动知觉。我们将结合使用“。具体目标1和2将表征在单独的光流刺激（视觉条件）、黑暗中的运动（前庭条件）和两种线索的组合组合期间神经元的3D调谐特性。此外，我们还将表征视觉或前庭信号的参考系。在目标3中，我们将使用精细运动方向辨别任务测试2 v区神经元活动和自我运动感知之间的直接联系。总之，这些研究将为2 v区是自我运动知觉神经基质的一部分这一假设提供重要的检验。拟议的研究旨在填补一个明显的知识空白，这对理解和治疗空间感知的认知缺陷很重要。