RFT5-DGA TO DEPLETE ALLOREACTIVE CELLS PRIOR TO HAPLOIDENTICAL STEM CELL TRANSP

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Administration of donor lymphocytes selectively depleted of alloreactive T-cells that can cause graft-versus-host disease (GVHD) results in improved immune function reconstitution and decreased disease relapse without causing severe GVHD in patients after haploidentical stem cell transplantation. Haploidentical stem cell transplantation is thus a viable alternative therapy for patients without other suitable stem cell donors.