PHASE I/II TRIAL OF R115777 AND XRT IN PEDIATRIC PATIENTS WITH NEWLY DIAGNOSE

R115777 和 XRT 在新诊断儿科患者中的 I/II 期试验

• 批准号: 7605870
• 负责人: SUSAN M. BLANEY
• 金额: $ 1.26万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-02-15 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7605870
• 关键词: Brain Stem Glioma; Childhood; Computer Retrieval of Information on Scientific Projects Database; Diffuse; Diffusion; Dose-Limiting; Farnesyl Transferase Inhibitor; Funding; Glioma; Grant; Image; Institution; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Measures; Mediating; Newly Diagnosed; Patients; Perfusion; Phase I/II Trial; Pontine structure; Positron-Emission Tomography; Progression-Free Survivals; R115777 (Zarnestra); Radiation; Radiation therapy; Radiation-Sensitizing Agents; Research; Research Personnel; Resources; Source; Toxic effect; United States National Institutes of Health; abstracting; tumor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. ABSTRACT HYPOTHESES The farnesyltransferase inhibitor, R115777, will function as a radiosensitizing agent in patients with brainstem gliomas. In addition, ras-mediated anti-tumor activity will be observed in brainstem gliomas following treatment with R115777. SPECIFIC AIMS Primary Objectives 1. To estimate the MTD of R115777 when administered to pediatric patients with nondisseminated, diffuse, intrinisc brainstem gliomas concurrently with radiation therapy with a limited dose escalation. 2. To assess the efficacy of R115777 treatment in combination with radiation therapy for patients with non-dissemianted, diffuse, intrinsic pontine gliomas as measured by progression-free survival. Secondary Objectives 3. To characterize toxicities associated with R115777 in combination with radiation therapy. 4. To characterize radiographic changes in brainstem gliomas treated with radiation and R115777 using MRI, MRS, perfusion and diffusion imaging and PET scans.

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