STRESS RESPONSE AND SMOKING CESSATION IN DEPRESSED YOUTH

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 吸烟往往始于青春期，并与重大的社会经济和心理社会负担有关，这突出表明需要及早进行有效的干预。尽管有证据表明药物，特别是一些抗抑郁(AD)药物对成年人有效，但这些戒烟方法并未在青少年中进行研究，也没有研究哪些年轻人将从这些治疗中受益最多。在考虑AD药物戒烟的作用机制时，HPA轴可能是重要的研究对象。HPA对压力和/或尼古丁给药的反应幅度已被证明调节尼古丁依赖的进展。此外，HPA调节与某些AD药物的反应之间也存在联系。 具体目标： 1)评估安非他酮是否有助于减少抑郁症青少年的吸烟。安非他酮是一种抗抑郁药物，也是一种被证明是戒烟的成年吸烟者的药物疗法。 2)研究在该人群中，下丘脑-垂体-肾上腺(HPA)调节是否与安非他酮戒烟有关。 3)探讨抑郁症青少年吸烟者在安非他酮治疗后HPA活性变化与戒烟的关系。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cigarette smoking frequently begins in adolescence and is associated with significant socioeconomic and psychosocial burden, highlighting the need for early and effective intervention. Despite evidence for efficacy of pharmacological agents, particularly some anti-depressant(AD) drugs, in adults, these treatments for smoking cessation have not been studied in youngsters, nor has it been studied which population of youth would benefit most from the treatments. In considering the mechanisms of action of AD drugs in smoking cessation, the HPA axis may be important for investigation. the magnitude of HPA response to stress and/or to nicotine administration has been shown to modulate the progression to nicotine dependence. Also, there is a connection between HPA regulation and response to some AD drugs. Specific Aims: 1) To evaluate whether bupropion, an anti-depressant drug that also is a proven pharmacological treatment for smoking cessation adult smokers, is helpful in reducing smoking in depressed adolescents. 2) To examine whether hypothalamic-pituitary-adrenal (HPA) regulation is associated with smoking cessation in response to bupropion in this population. 3) To examine the association between smoking cessation and HPA activity changes in response to bupropion treatment in depressed adolescent smokers.