ROSIGLITAZONE VS PLACEBO: EFFECT OF CV PERFORMANCE AND MYOCARDIAL TRIGLYCERIDE

罗格列酮与安慰剂：对心血管性能和心肌甘油三酯的影响

• 批准号: 7606341
• 负责人: Darren K McGuire
• 金额: $ 1.31万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7606341
• 关键词: Cardiac; Cardiac Myocytes; Cardiovascular Diseases; Cardiovascular system; Clinical Research; Collaborations; Computer Retrieval of Information on Scientific Projects Database; Deposition; Double-Blind Method; Exercise; Funding; Grant; Heart; Hospitals; Hyperglycemia; Institution; Lipids; Magnetic Resonance Imaging; Myocardial; Non-Insulin-Dependent Diabetes Mellitus; Nuclear Magnetic Resonance; Outpatients; Oxygen; Patients; Performance; Pharmaceutical Preparations; Placebo Control; Placebo Effect; Placebos; Randomized; Research; Research Infrastructure; Research Personnel; Resources; Source; Structure; Techniques; Treadmill Tests; Triglycerides; United States National Institutes of Health; Woman; base; cardiovascular risk factor; improved; rosiglitazone; uptake

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary objectives of this study are to determine if 6 months of treatment with rosiglitazone, a thiazolidmedione medication commonly used in the treatment of hyperglycemia of type 2 diabetes, versus placebo in patients with cardiovascular disease or with an additional cardiovascular risk factor 1) improves integrated cardiovascular performance, assessed by peak oxygen uptake during exercise treadmill testing; 2) effects cardiac structure and function as assess by MRI; and 3) decreases intracellular (ectopic) triglyceride deposition in cardiomyocytes using nuclear magnetic resonance techniques, and how changes in intra-myocardial lipid content relate to changes in cardiac structure and function. This multi-center randomized placebo-controlled double-blinded parallel group study will use the clinical research infrastructure and resources developed in the Donal W. Reynolds Cardiovascular Clinical Research Center at UT Southwestern, and the collaborative participation of the other 3 Reynolds Centers - Stanford, Brigham and Women's Hospital, and Johns Hopkins. Based on the precedent of collaboration established between the UT Southwestern Reynolds Center and the GCRC in the Dallas Heart Study (SPID 0645), GCRC resources will again be utilized for Core Lab and occasional outpatient resources only at UT Southwestern.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本研究的主要目的是确定在患有心血管疾病或具有额外的心血管危险因素的患者中，与安慰剂相比，罗格列酮（一种常用于治疗2型糖尿病高血糖症的噻唑烷二酮类药物）治疗6个月是否改善了综合心血管功能，通过运动平板试验期间的峰值摄氧量评估; 2）通过MRI评估影响心脏结构和功能;和3）使用核磁共振技术减少心肌细胞中的细胞内（异位）甘油三酯沉积，以及心肌内脂质含量的变化如何与心脏结构和功能的变化相关。 这项多中心随机安慰剂对照双盲平行组研究将使用Donal W开发的临床研究基础设施和资源。犹他州西南部的雷诺兹心血管临床研究中心，以及其他3个雷诺兹中心-斯坦福大学、布里格姆妇女医院和约翰霍普金斯的合作参与。 根据UT西南雷诺兹中心和GCRC在达拉斯心脏研究（SPID 0645）中建立的合作先例，GCRC资源将再次用于核心实验室，偶尔仅用于UT西南的门诊资源。