NOCTURNAL SECRETION OF OVARIAN STEROIDS, LH, AND FSH IN ADOLESCENT GIRLS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 青春期高雄激素血症似乎是多囊卵巢综合征（PCOS）的前兆。PCOS患者对孕酮抑制GnRH脉动的敏感性降低，可能是由于雄激素水平升高，因为雄激素受体阻断可使GnRH敏感性恢复正常。我们的目的是研究青春期有或没有雄激素升高的青春期女孩的卵巢类固醇、LH和FSH的夜间分泌模式。这些结果将促进我们对PCOS原因的了解。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Adolescent hyperandrogenemia appears to be a precursor to polycystic ovary syndrome (PCOS). Women with PCOS have a reduced sensitivity to progesterone inhibition of GnRH pulsatility, likely due to elevated levels of androgens, as GnRH sensitivity can be restored to normal by androgen receptor blockade. We aim to examine the nocturnal secretory patterns of ovarian steroids, LH, & FSH in adolescent girls with or without elevated androgens during puberty. The results will advance our knowledge of the causes of PCOS.