OBSERVATIONAL STUDY OF SUBJECTS WITH PRIMARY HIV INFECTION

原发性 HIV 感染受试者的观察性研究

• 批准号: 7606564
• 负责人: SUSAN E LITTLE
• 金额: $ 57.03万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7606564
• 关键词: Acute; Cerebrospinal Fluid; Computer Retrieval of Information on Scientific Projects Database; Etiology; Funding; Genetic; Genotype; Grant; HIV; HIV Infections; Individual; Infection; Institution; Interruption; Lymphocyte; Natural History; Observational Study; Outcome; Pathogenesis; Research; Research Personnel; Resources; Source; Study Subject; Tissues; United States National Institutes of Health; Vagina; Viral; antiretroviral therapy; monocyte; response; treatment effect

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. To characterize the viral dynamics and immulogical response of HIV-infected circulating lymphocytes and monocytes during acute and early HIV infection and following the initiation or interruption of potent antiretroviral therapy. To determine the relationship between the dynamics of circulating HIV and other tissue compartments for HIV, including cerebrospinal fluid, and smene and vaginal secretions during acute and early HIV infection. To characterize the genetic variance of HIV viral genotypes in the circulatory compartment of identified transmitters of HIV to individuals with primary HIV infection, as well as circulating and tissue compartments for HIV. To describe the natural history, etiology, pathogenesis, treatment effects and long term outcomes of acute/early HIV infection in the era of potent antiretroviral therapy.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 表征急性和早期 HIV 感染期间以及开始或中断有效抗逆转录病毒治疗后 HIV 感染的循环淋巴细胞和单核细胞的病毒动态和免疫反应。 确定急性和早期艾滋病毒感染期间循环艾滋病毒和艾滋病毒其他组织区室的动态之间的关系，包括脑脊液、精液和阴道分泌物。 旨在表征已确定的 HIV 传播者的循环区室中 HIV 病毒基因型的遗传变异，以及 HIV 的循环区室和组织区室。 描述有效抗逆转录病毒治疗时代急性/早期艾滋病毒感染的自然史、病因、发病机制、治疗效果和长期结果。