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Natural History of Borrelia lonestari

孤独疏螺旋体的自然历史

基本信息

批准号：
7211134
负责人：
SUSAN E LITTLE
金额：
$ 34.18万
依托单位：
OKLAHOMA STATE UNIVERSITY STILLWATER
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-06-01 至 2008-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7211134
关键词：
Borrelia human infection model ticks

项目摘要

DESCRIPTION (provided by the applicant): Southern tick-associated rash illness (STARI) is a newly-described Lyme disease-like infection reported from the southeastern and south central United States caused by Borrelia Ionestari. Our long-range goal is to understand the risk factors that conspire to allow maintenance of tick-borne bacterial pathogens in nature and transmission of these pathogens from the reservoir host-tick vector maintenance cycle to people. As our next objective in pursuit of this goal, we propose in this application to delineate the natural history of Borrelia Ionestari. Our central hypothesis is that Borrelia Ionestari is maintained in nature through a cycle involving white-tailed deer as primary reservoir host and lone star ticks as predominant vector, and that this system can be exploited to develop a geographic information system (GIS)-based model that predicts areas where humans are at greatest risk of infection. The rationale behind the proposed research is that field and experimental infection data collected to date indicate infection with Borrelia Ionestari is maintained in a deer-lone star tick reservoir system. To accomplish the objectives of this application, we will pursue four specific aims: (1) confirm that Borrelia Ionestari is maintained in a cycle involving white-tailed deer as reservoir host and lone star ticks as vector; (2) define the geographic distribution of Borrelia Ionestari in the United States using white-tailed deer as sentinels and lone star ticks as confirmatory indicators of the presence of infection in an area; (3) identify other potential wild vertebrate reservoir hosts and tick vectors that may be involved in the natural history of Borrelia Ionestari; and (4) evaluate rodents as a potential model for experimental infection with Borrelia Ionestari. At the completion of this research, we expect to have fully delineated the natural history of Borrelia Ionestari We also expect to have defined the geographic distribution of this pathogen in a manner that both examines the landscape epidemiology of this organism in detail and allows identification of areas where risk of human infection is high. Ultimately, the model of the natural history of Borrelia Ionestari gained from the proposed research will improve understanding of both STARI and Lyme borreliosis in the southern U.S., enhancing public health efforts in those areas where people are risk of infection; reduction in human disease from these pathogens should result.

描述（由申请人提供）：南方蜱相关皮疹病（STARI）是一种新描述的莱姆病样感染，据报道，由美国东南部和中南部伯氏疏螺旋体引起。我们的长期目标是了解导致蜱传细菌病原体在自然界中得以维持以及这些病原体从储存宿主-蜱载体维持周期传播给人类的风险因素。作为我们追求这一目标的下一个目标，我们在本申请中建议描绘伯氏疏螺旋体的自然历史。我们的中心假设是，Borrelia Ionestari 通过一个以白尾鹿为主要储存宿主、以孤星蜱为主要媒介的循环在自然界中得以维持，并且可以利用该系统开发基于地理信息系统 (GIS) 的模型，预测人类感染风险最大的区域。这项研究背后的基本原理是，迄今为止收集的现场和实验感染数据表明，鹿孤星蜱储存系统中维持着疏螺旋体的感染。为了实现本申请的目标，我们将追求四个具体目标：（1）确认Borrelia Ionestari维持在一个以白尾鹿为储存宿主、以孤星蜱为媒介的循环中； (2) 使用白尾鹿作为哨兵，使用孤星蜱作为某个地区存在感染的确认指标，确定爱氏疏螺旋体在美国的地理分布； (3) 确定可能与疏螺旋体自然史有关的其他潜在野生脊椎动物储存宿主和蜱媒介； (4) 评估啮齿类动物作为实验性疏螺旋体感染的潜在模型。在这项研究完成后，我们希望能够充分描述伯氏疏螺旋体的自然史。我们还希望能够以一种既详细检查这种生物体的景观流行病学又可以识别人类感染风险高的地区的方式来定义这种病原体的地理分布。最终，从拟议的研究中获得的 Borrelia Ionestari 自然史模型将提高对美国南部 STARI 和莱姆疏螺旋体病的了解，加强人们有感染风险的地区的公共卫生工作；应该会减少这些病原体引起的人类疾病。