OBSERVATIONAL STUDY OF SUBJECTS WITH PRIMARY HIV INFECTION

原发性 HIV 感染受试者的观察性研究

• 批准号: 7724919
• 负责人: SUSAN E LITTLE
• 金额: $ 0.25万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-12-01 至 2008-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7724919
• 关键词: Acute; Cerebrospinal Fluid; Computer Retrieval of Information on Scientific Projects Database; Etiology; Funding; Genetic; Genotype; Grant; HIV; HIV Infections; Individual; Infection; Institution; Interruption; Lymphocyte; Natural History; Observational Study; Outcome; Pathogenesis; Research; Research Personnel; Resources; Source; Study Subject; Tissues; United States National Institutes of Health; Vagina; Viral; antiretroviral therapy; monocyte; response; treatment effect

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. To characterize the viral dynamics and immulogical response of HIV-infected circulating lymphocytes and monocytes during acute and early HIV infection and following the initiation or interruption of potent antiretroviral therapy. To determine the relationship between the dynamics of circulating HIV and other tissue compartments for HIV, including cerebrospinal fluid, and smene and vaginal secretions during acute and early HIV infection. To characterize the genetic variance of HIV viral genotypes in the circulatory compartment of identified transmitters of HIV to individuals with primary HIV infection, as well as circulating and tissue compartments for HIV. To describe the natural history, etiology, pathogenesis, treatment effects and long term outcomes of acute/early HIV infection in the era of potent antiretroviral therapy.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 目的：研究HIV感染的血液中淋巴细胞和单核细胞在HIV急性感染和早期感染以及开始或停止有效的抗逆转录病毒治疗后的病毒动力学和免疫反应。 目的：探讨在HIV急性感染和早期感染过程中，HIV循环与包括脑脊液、女性分泌物和阴道分泌物在内的HIV其他组织器官之间的关系。 描述已确定的艾滋病毒传播者对原发艾滋病毒感染者的循环系统中HIV病毒基因分型的遗传变异，以及HIV的循环系统和组织系统。 描述在有效的抗逆转录病毒治疗时代，急性/早期艾滋病毒感染的自然历史、病原学、发病机制、治疗效果和长期结果。