OBSERVATIONAL STUDY OF SUBJECTS WITH PRIMARY HIV INFECTION

原发性 HIV 感染受试者的观察性研究

• 批准号: 7724919
• 负责人: SUSAN E LITTLE
• 金额: $ 0.25万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-12-01 至 2008-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7724919
• 关键词: Acute; Cerebrospinal Fluid; Computer Retrieval of Information on Scientific Projects Database; Etiology; Funding; Genetic; Genotype; Grant; HIV; HIV Infections; Individual; Infection; Institution; Interruption; Lymphocyte; Natural History; Observational Study; Outcome; Pathogenesis; Research; Research Personnel; Resources; Source; Study Subject; Tissues; United States National Institutes of Health; Vagina; Viral; antiretroviral therapy; monocyte; response; treatment effect

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. To characterize the viral dynamics and immulogical response of HIV-infected circulating lymphocytes and monocytes during acute and early HIV infection and following the initiation or interruption of potent antiretroviral therapy. To determine the relationship between the dynamics of circulating HIV and other tissue compartments for HIV, including cerebrospinal fluid, and smene and vaginal secretions during acute and early HIV infection. To characterize the genetic variance of HIV viral genotypes in the circulatory compartment of identified transmitters of HIV to individuals with primary HIV infection, as well as circulating and tissue compartments for HIV. To describe the natural history, etiology, pathogenesis, treatment effects and long term outcomes of acute/early HIV infection in the era of potent antiretroviral therapy.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 为了表征急性和早期HIV感染期间HIV感染的循环淋巴细胞和单核细胞的病毒动力学和免疫反应，以及在有效的抗逆转录病毒疗法的引发或中断之后。 确定循环HIV的动力学与其他组织室的动力学（包括脑脊液液体）以及急性和早期HIV感染期间的Smene和阴道分泌物之间的关系。 为了表征HIV病毒基因型在鉴定出HIV的发射机的循环室中的遗传方差，以及艾滋病毒原发性HIV感染的个体，以及HIV的循环和组织室。 描述在有效的抗逆转录病毒治疗时代，急性/早期HIV感染的自然史，病因，病因，治疗效果和长期结局。