OBSERVATIONAL STUDY OF SUBJECTS WITH PRIMARY HIV INFECTION

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 描述急性和早期HIV感染期间以及开始或中断强效抗逆转录病毒治疗后HIV感染循环淋巴细胞和单核细胞的病毒动力学和免疫应答。 确定在急性和早期HIV感染期间，循环HIV和HIV的其他组织隔室（包括脑脊液）以及smene和阴道分泌物的动态之间的关系。 描述HIV病毒基因型在已确定的HIV传播者的循环区室中对原发性HIV感染个体的遗传变异，以及HIV的循环区室和组织区室。 描述在强效抗逆转录病毒治疗时代，急性/早期HIV感染的自然史、病因、发病机制、治疗效果和长期结局。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. To characterize the viral dynamics and immulogical response of HIV-infected circulating lymphocytes and monocytes during acute and early HIV infection and following the initiation or interruption of potent antiretroviral therapy. To determine the relationship between the dynamics of circulating HIV and other tissue compartments for HIV, including cerebrospinal fluid, and smene and vaginal secretions during acute and early HIV infection. To characterize the genetic variance of HIV viral genotypes in the circulatory compartment of identified transmitters of HIV to individuals with primary HIV infection, as well as circulating and tissue compartments for HIV. To describe the natural history, etiology, pathogenesis, treatment effects and long term outcomes of acute/early HIV infection in the era of potent antiretroviral therapy.