SYSTEMIC IRON METABOLISM IN RESTLESS LEGS SYNDROME

不宁腿综合征的全身铁代谢

• 批准号: 7607473
• 负责人: CHRISTOPHER J EARLEY
• 金额: $ 0.34万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7607473
• 关键词: Computer Retrieval of Information on Scientific Projects Database; Excretory function; Ferritin; Funding; Grant; Institution; Iron; Kidney; Oral; Patients; Plasma; Relative (related person); Research; Research Personnel; Resources; Restless Legs Syndrome; Source; United States National Institutes of Health; absorption; iron metabolism

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. These investigators have demonstrated that iron metabolism differs in subjects with Restless Leg syndrome (RLS). They seek now to further characterize the mechanism of the relative iron deficiency observed in RLS. Patients with RLS may have reduced iron either from reduced absorption, increased turnover or increased excretion. These investigators hypothesize that RLS patients have lower absorption of oral iron than normal subjects when controlling for ferritin levels. Furthermore, they hypothesize that the apparent loss of iron observed in RLS patients is due to increased renal excretion of iron. In addition, the investigators hypothesize that RLS subjects will demonstrate a more rapid elimination or turnover of iron from the plasma pool than seen in normal subjects.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 这些研究人员已经证明，不宁腿综合征 (RLS) 受试者的铁代谢存在差异。他们现在寻求进一步描述 RLS 中观察到的相对铁缺乏的机制。 不宁腿综合征患者的铁含量可能因吸收减少、周转增加或排泄增加而减少。 这些研究人员推测，在控制铁蛋白水平时，RLS 患者对口服铁的吸收率低于正常受试者。此外，他们推测在不宁腿综合征患者中观察到的明显铁损失是由于肾脏铁排泄增加所致。此外，研究人员推测，与正常受试者相比，不宁腿综合征受试者血浆中铁的消除或周转速度更快。