SYSTEMIC IRON METABOLISM IN RESTLESS LEGS SYNDROME

不宁腿综合征的全身铁代谢

• 批准号: 7607473
• 负责人: CHRISTOPHER J EARLEY
• 金额: $ 0.34万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7607473
• 关键词: Computer Retrieval of Information on Scientific Projects Database; Excretory function; Ferritin; Funding; Grant; Institution; Iron; Kidney; Oral; Patients; Plasma; Relative (related person); Research; Research Personnel; Resources; Restless Legs Syndrome; Source; United States National Institutes of Health; absorption; iron metabolism

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. These investigators have demonstrated that iron metabolism differs in subjects with Restless Leg syndrome (RLS). They seek now to further characterize the mechanism of the relative iron deficiency observed in RLS. Patients with RLS may have reduced iron either from reduced absorption, increased turnover or increased excretion. These investigators hypothesize that RLS patients have lower absorption of oral iron than normal subjects when controlling for ferritin levels. Furthermore, they hypothesize that the apparent loss of iron observed in RLS patients is due to increased renal excretion of iron. In addition, the investigators hypothesize that RLS subjects will demonstrate a more rapid elimination or turnover of iron from the plasma pool than seen in normal subjects.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这些研究人员已经证明，患有不宁腿综合征(RLS)的受试者铁代谢不同。他们现在试图进一步描述在RLS中观察到的相对缺铁的机制。RLS患者可能由于吸收减少、周转增加或排泄增加而减少了铁。这些研究人员假设，在控制铁蛋白水平时，RLS患者对口服铁的吸收低于正常受试者。此外，他们假设在RLS患者中观察到的明显铁丢失是由于肾脏铁排泄增加所致。此外，研究人员假设，RLS受试者将比正常受试者更快地从血浆池中排出或周转铁。