SLEEP RESTRICTION IN CONTROLS

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。PI进行的既往研究表明，RLS患者和对照受试者在嗜睡指标（认知评估和SIT测试）方面无差异。这些研究受到一个重要因素的混淆：RLS患者平均每晚睡眠6小时，而对照组睡眠时间正常（每晚6-8小时）。本研究的目的是比较RLS患者和对照组在控制睡眠时间的同时对嗜睡的测量。特别是，对照受试者在进入GCRC之前将经历10天的睡眠限制，在那里他们和匹配的RLS患者将经历认知功能评估、SIT测试和MRI研究。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Previous studies conducted by the PI suggest that patients with RLS and control subjects do not differ on measures of sleepiness(cognitive assessments and SIT tests). These studies are confounded by an important factor: Patients with RLS have, on average, 6 hours of sleep per night, whereas controls have normal sleep durations (6-8 hours per night). The purpose of this study is to compare patients with RLS and controls on measures of sleepiness while controlling for sleep duration. In particular, control subjects will undergo a 10 day period of sleep restriction prior to admission to the GCRC, where they and matched RLS patients will undergo assessments of cognitive function, SIT testing, and MRI studies.