Restless Legs Syndrome Scientific Meeting

描述（由申请人提供）：1997年2月22日，第一次不宁腿综合征（RLS）科学会议在华盛顿的国家科学院举行。十年前，RLS是一个家喻户晓的名字。正因为如此，当时成立五年的RLS基金会决定组织一次会议，以激发其他领域顶级研究人员对这种相对闻所未闻的情况的兴趣。RLS基金会是一个非营利的501（c）3组织，致力于改善患有这种毁灭性疾病的男性，女性和儿童的生活。该组织的目标是提高对不宁腿综合征的认识，改善治疗方法，并通过研究找到治愈方法。该提案的目的是请求国家卫生研究所支持召开第二次RLS科学会议。在过去的十年里，RLS的研究取得了令人难以置信的进展。由RLS基金会部分资助的研究人员最近宣布发现了第一个显著增加RLS风险的基因变异。我们现在也了解到，RLS与大脑黑质中的铁缺乏密切相关，这是我们十年前不了解的。此外，医疗保健提供者现在有很好的流行病学信息：a）确定确切的问题，必须问一个得到一个准确的诊断RLS;和B）查明RLS的发病率在美国人口。第二次会议的目标是：（1）将RLS基金会赠款接受者聚集在一起，总结过去10年所做的工作;（2）评估现有的假设，并考虑发展关于RLS原因的新假设;（3）吸引新的研究人员进入RLS领域;以及（4）为RLS基金会的研究计划制定研究优先事项并阐明重点领域。 公共卫生相关性：RLS科学会议反映了2010年健康人的目标：残疾和继发性疾病。会议的目标是为未来的RLS研究创建一个路线图，该路线图包含在HP 2010目标中，以促进残疾人的健康，预防继发性疾病，并消除美国残疾人和非残疾人之间的差距。

DESCRIPTION (provided by applicant): It was on February 22, 1997 that the first Restless legs syndrome (RLS) Scientific Meeting was held at the National Academy of Sciences in Washington D.C. A decade ago, RLS was anything but a household name. Because of this, the then five-year-old RLS Foundation decided to organize a meeting to spark interest in this relatively unheard of condition among top level researchers in other fields. The RLS Foundation, a nonprofit 501(c)3 organization, is dedicated to improving the lives of the men, women, and children who live with this often devastating disease. The organization's goals are to increase awareness of restless legs syndrome, to improve treatments, and, through research, find a cure. The purpose of this proposal is to request the National Institute of Health's support to convene a second scientific meeting on RLS. The last ten years have seen incredible progress in the study of RLS. Researchers, funded in part of the RLS Foundation, recently announced the discovery of the first gene variant that contributes substantially to risk for RLS. We also now understand that RLS correlates heavily with iron deficiencies in the brain's substantial nigra, something that we did not understand ten years ago. In addition, healthcare providers now have excellent epidemiology information that: a) identifies the exact questions one must ask to get an accurate diagnosis of RLS; and b) pinpoints the incidence of RLS in the American population. The goals of this second meeting would be to: (1) bring RLS Foundation grantee recipients together to summarize what has been done in the past 10 years; (2) evaluate the existing hypotheses and consider the development of new hypotheses as to the cause of RLS; (3) attract new researchers into the field of RLS; and (4) develop research priorities and articulate areas of focus for the RLS Foundation's research program. PUBLIC HEALTH RELEVANCE: The RLS Science Meeting reflects the goals of Healthy People 2010: Disability and Secondary Conditions. The goal of the meeting to create a roadmap for future RLS research is contained within the HP 2010 goal to promote the health of people with disabilities, prevent secondary conditions, and eliminate disparities between people with and without disabilities in the United States.