DOPAMINE/RESTLESS LEG SYNDROME

多巴胺/不宁腿综合症

• 批准号: 7604602
• 负责人: CHRISTOPHER J EARLEY
• 金额: $ 0.26万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604602
• 关键词: Brain; Circadian Rhythms; Computer Retrieval of Information on Scientific Projects Database; Dopamine; End stage renal failure; Financial compensation; Functional disorder; Funding; Grant; Institution; Iron; Population; Pregnancy; Prevalence; Reporting; Research; Research Personnel; Resources; Restless Legs Syndrome; Role; Sensory; Source; Symptoms; System; Testing; Time; United States National Institutes of Health; day; motor disorder; nervous system disorder

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Restless Legs Syndrome (RLS) is a neurological disorder that is reported to effect between 2-5% of the population. RLS is a sensory-motor disorder that respond to dopamine treatment. RLS prevalence is consistently higher that the population prevalence for iron deficiency, pregnancy, and end-stage renal disease. Although the pathophysiology of RLS remains unknown, evidence does suggest a role for the dopaminergic (DA) system for brain iron deficiency. We propose to test that RLS symptoms are a result of compensation for an increase in the circadian amplitude of dopaminergic activity. We propose that there is a dynamic change in the system over its circadian cycle, not just a single time-of-day decrement in dopamine at night.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 不宁腿综合征（RLS）是一种神经系统疾病，据报道影响2-5%的人口。 RLS是一种对多巴胺治疗有反应的感觉运动障碍。 RLS患病率始终高于缺铁、妊娠和终末期肾病的人群患病率。 虽然RLS的病理生理学仍然未知，但有证据表明多巴胺能（DA）系统在脑缺铁中发挥作用。 我们建议测试，RLS症状是一个结果的补偿增加的昼夜节律的多巴胺能活动的振幅。 我们认为，在其昼夜节律周期中，系统中存在动态变化，而不仅仅是夜间多巴胺的单一时间减少。