DOPAMINE/RESTLESS LEG SYNDROME

多巴胺/不宁腿综合症

• 批准号: 7604602
• 负责人: CHRISTOPHER J EARLEY
• 金额: $ 0.26万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604602
• 关键词: Brain; Circadian Rhythms; Computer Retrieval of Information on Scientific Projects Database; Dopamine; End stage renal failure; Financial compensation; Functional disorder; Funding; Grant; Institution; Iron; Population; Pregnancy; Prevalence; Reporting; Research; Research Personnel; Resources; Restless Legs Syndrome; Role; Sensory; Source; Symptoms; System; Testing; Time; United States National Institutes of Health; day; motor disorder; nervous system disorder

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Restless Legs Syndrome (RLS) is a neurological disorder that is reported to effect between 2-5% of the population. RLS is a sensory-motor disorder that respond to dopamine treatment. RLS prevalence is consistently higher that the population prevalence for iron deficiency, pregnancy, and end-stage renal disease. Although the pathophysiology of RLS remains unknown, evidence does suggest a role for the dopaminergic (DA) system for brain iron deficiency. We propose to test that RLS symptoms are a result of compensation for an increase in the circadian amplitude of dopaminergic activity. We propose that there is a dynamic change in the system over its circadian cycle, not just a single time-of-day decrement in dopamine at night.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 不宁腿综合症 (RLS) 是一种神经系统疾病，据报道影响 2-5% 的人口。 RLS 是一种对多巴胺治疗有反应的感觉运动障碍。 RLS 患病率始终高于缺铁、妊娠和终末期肾病的人群患病率。 尽管 RLS 的病理生理学仍不清楚，但有证据表明多巴胺能 (DA) 系统在脑缺铁中发挥着重要作用。 我们建议测试 RLS 症状是否是多巴胺能活动昼夜节律幅度增加补偿的结果。 我们认为，系统在其昼夜节律周期中存在动态变化，而不仅仅是夜间多巴胺的单一时间减少。