DOPAMINE AND IRON IN RESTLESS LEG SYNDROME

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 不宁腿综合征（RLS）是一种常见的睡眠障碍，据报道影响2%至5%的人口。 虽然RLS的病理生理学尚不清楚，但有大量的临床前和临床研究强烈暗示脑DA系统，并且有证据表明脑铁缺乏也可能起作用。 拟议的研究将使用正电子发射断层扫描（PET）方法与多巴胺2受体（D2 R）和多巴胺转运蛋白（DAT）的放射性配体选择性，前和后的药物挑战与d-苯丙胺，以评估状态的大脑多巴胺系统与匹配的对照组相比，在RLS患者。 此外，磁共振光谱（MRS）方法，沿着铁蛋白的脑脊液测量将用于测量CNS铁，催乳素的系列血浆测量将用作结节漏斗DA活性的间接测量。 该项目的总体目标是更好地描述RLS患者的多巴胺能功能障碍及其与CNS铁含量的关系。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Restless legs syndrome (RLS) is a common sleep disorder that is reported to effect beween 2 and 5% of the population. Although the pathophysiology of RLS is unknown, there is a significant body of preclinical and clinical research that strongly implicates the brain DA system, and some evidence that brain iron deficiency may also play a role. The proposed research will use positron emission tomographic (PET) methods with radioligands selective for the dopamine 2 receptor (D2R) and the dopamine transporter (DAT), pre- and post- pharmacological challenge with d-amphetamine, to assess the status of the brain dopamine systems in patients with RLS compared to matched controls. In addition, magnetic resonance spectroscopic (MRS) methods, along with cerebrospinal measures of ferritin will be used to measure CNS iron, and serial plasma measures of prolactin will be used as an indirect measure of tuberoinfundibular DA activity. The overarching goals of the project are to better characterize dopaminergic dysfunction in patients with RLS, and its relationship to CNS iron content.