DOPAMINE AND IRON IN RESTLESS LEG SYNDROME

多巴胺和铁在不宁腿综合症中的作用

• 批准号: 7607461
• 负责人: CHRISTOPHER J EARLEY
• 金额: $ 0.21万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7607461
• 关键词: Brain; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Dextroamphetamine; Dopamine; Ferritin; Functional disorder; Funding; Goals; Grant; Institution; Iron; Magnetic Resonance; Measures; Methods; Patients; Plasma; Play; Population; Positron; Prolactin; Reporting; Research; Research Personnel; Resources; Restless Legs Syndrome; Role; Sleep Disorders; Source; System; United States National Institutes of Health; dopamine system; dopamine transporter; pre-clinical; radioligand; receptor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Restless legs syndrome (RLS) is a common sleep disorder that is reported to effect beween 2 and 5% of the population. Although the pathophysiology of RLS is unknown, there is a significant body of preclinical and clinical research that strongly implicates the brain DA system, and some evidence that brain iron deficiency may also play a role. The proposed research will use positron emission tomographic (PET) methods with radioligands selective for the dopamine 2 receptor (D2R) and the dopamine transporter (DAT), pre- and post- pharmacological challenge with d-amphetamine, to assess the status of the brain dopamine systems in patients with RLS compared to matched controls. In addition, magnetic resonance spectroscopic (MRS) methods, along with cerebrospinal measures of ferritin will be used to measure CNS iron, and serial plasma measures of prolactin will be used as an indirect measure of tuberoinfundibular DA activity. The overarching goals of the project are to better characterize dopaminergic dysfunction in patients with RLS, and its relationship to CNS iron content.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 不宁腿综合症(RLS)是一种常见的睡眠障碍，据报道，影响到2%到5%的人口。虽然RLS的病理生理学机制尚不清楚，但有大量的临床前和临床研究强烈地涉及到大脑DA系统，一些证据表明大脑缺铁也可能起作用。这项拟议的研究将使用正电子发射断层扫描(PET)方法，通过选择多巴胺2受体(D2R)和多巴胺转运体(DAT)的放射性配体，在药物治疗前后用d-苯丙胺挑战，与匹配的对照组相比，评估RLS患者的脑多巴胺系统的状态。此外，磁共振波谱(MRS)方法以及脑脊液中铁蛋白的测量将被用于测量中枢神经系统铁，而催乳素的一系列血浆测量将被用于间接测量漏斗状结节中DA的活性。该项目的总体目标是更好地描述RLS患者的多巴胺能功能障碍，以及它与中枢神经系统铁含量的关系。