DOPAMINE-RLS CONNECTION

多巴胺-RLS 连接

• 批准号: 7604739
• 负责人: CHRISTOPHER J EARLEY
• 金额: $ 0.02万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604739
• 关键词: Age; Arts; Autopsy; Brain; Clinical; Computer Retrieval of Information on Scientific Projects Database; Corpus striatum structure; Data; Dopamine; Dopamine Antagonists; Funding; Grant; Imaging Techniques; Institution; Iron; Magnetic Resonance Imaging; Measures; Midbrain structure; Patients; Phase; Play; Positron-Emission Tomography; Production; Research; Research Personnel; Resources; Restless Legs Syndrome; Role; Sensory; Severities; Source; Symptoms; System; United States National Institutes of Health; Ventral Striatum; day; design; dopamine system; ferryl iron; motor disorder; receptor binding; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Restless Legs Syndrome (RLS) is a sensory-motor disorder in which the dopaminergic system and brain iron appear to play a role. The dramatic symptomatic response to L-DOPA in over 98% of RLS subjects and the induction of RLS-like symptoms with dopamine (DA) antagonists provide convincing evidence for the role of the dopaminergic system in the production of RLS symptoms per se. The autopsy, CSF, MRI, and IV iron treatment data indicate a role of BRAIN iron deficiency in RLS. This study is designed to explore for abnormalities in the nigrostriatal (PET imaging of midbrain and striatum) and mesolimbic (PET imaging of ventral striatum/n. accumbens) Dopaminergic systems during the day. The DA-2 receptor (D2R) binding potential and Bmax, and DAT will be measured with state-of-the-art PET imaging techniques from 8:30-12 am. Any changes that are found in the DA system will be correlated with MRI measures of regional brain iron concentrations and measures of clinical severity. Idiopathic RLS patients and aged-matched controls will be studied in this Phase.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 不宁腿综合症 (RLS) 是一种感觉运动障碍，其中多巴胺能系统和脑铁似乎发挥了作用。 超过 98% 的 RLS 受试者对左旋多巴的显着症状反应以及多巴胺 (DA) 拮抗剂诱导的 RLS 样症状为多巴胺能系统在 RLS 症状本身产生中的作用提供了令人信服的证据。 尸检、脑脊液、MRI 和静脉铁剂治疗数据表明，大脑缺铁在不宁腿综合症中发挥着重要作用。 本研究旨在探讨白天黑质纹状体（中脑和纹状体 PET 成像）和中脑边缘（腹侧纹状体/伏隔神经元 PET 成像）多巴胺能系统的异常情况。 DA-2 受体 (D2R) 结合潜力、Bmax 和 DAT 将在上午 8:30-12 点使用最先进的 PET 成像技术进行测量。 DA 系统中发现的任何变化都将与区域脑铁浓度的 MRI 测量值和临床严重程度的测量值相关。 本阶段将研究特发性 RLS 患者和年龄匹配的对照。