DOPAMINE-RLS CONNECTION

多巴胺-RLS 连接

• 批准号: 7604739
• 负责人: CHRISTOPHER J EARLEY
• 金额: $ 0.02万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604739
• 关键词: Age; Arts; Autopsy; Brain; Clinical; Computer Retrieval of Information on Scientific Projects Database; Corpus striatum structure; Data; Dopamine; Dopamine Antagonists; Funding; Grant; Imaging Techniques; Institution; Iron; Magnetic Resonance Imaging; Measures; Midbrain structure; Patients; Phase; Play; Positron-Emission Tomography; Production; Research; Research Personnel; Resources; Restless Legs Syndrome; Role; Sensory; Severities; Source; Symptoms; System; United States National Institutes of Health; Ventral Striatum; day; design; dopamine system; ferryl iron; motor disorder; receptor binding; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Restless Legs Syndrome (RLS) is a sensory-motor disorder in which the dopaminergic system and brain iron appear to play a role. The dramatic symptomatic response to L-DOPA in over 98% of RLS subjects and the induction of RLS-like symptoms with dopamine (DA) antagonists provide convincing evidence for the role of the dopaminergic system in the production of RLS symptoms per se. The autopsy, CSF, MRI, and IV iron treatment data indicate a role of BRAIN iron deficiency in RLS. This study is designed to explore for abnormalities in the nigrostriatal (PET imaging of midbrain and striatum) and mesolimbic (PET imaging of ventral striatum/n. accumbens) Dopaminergic systems during the day. The DA-2 receptor (D2R) binding potential and Bmax, and DAT will be measured with state-of-the-art PET imaging techniques from 8:30-12 am. Any changes that are found in the DA system will be correlated with MRI measures of regional brain iron concentrations and measures of clinical severity. Idiopathic RLS patients and aged-matched controls will be studied in this Phase.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 不宁腿综合征（RLS）是一种感觉运动障碍，其中多巴胺能系统和脑铁似乎发挥作用。 在超过98%的RLS受试者中对L-DOPA的戏剧性症状反应和用多巴胺（DA）拮抗剂诱导RLS样症状为多巴胺能系统在RLS症状本身的产生中的作用提供了令人信服的证据。 尸检、CSF、MRI和IV铁治疗数据表明脑铁缺乏在RLS中的作用。 本研究旨在探索黑质纹状体（中脑和纹状体的PET成像）和中脑边缘（腹侧纹状体的PET成像/n.多巴胺能系统在白天。 从上午8：30-12：00，采用最先进的PET成像技术测量DA-2受体（D2 R）结合电位和Bmax以及DAT。 在DA系统中发现的任何变化将与局部脑铁浓度的MRI测量和临床严重程度的测量相关。 特发性RLS患者和年龄匹配的对照将在本阶段进行研究。