FUNCTIONAL ACTIVITY OF AIRWAY EOSINOPHILS IN ALLERGIC DISEASE

过敏性疾病中气道嗜酸性粒细胞的功能活性

• 批准号: 7607564
• 负责人: William W. Busse
• 金额: $ 0.05万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7607564
• 关键词: Allergic; Asthma; Cells; Complex; Computer Retrieval of Information on Scientific Projects Database; Disease; Funding; Goals; Grant; Hypersensitivity; Institution; Laboratory Study; Lung; Mucous body substance; Protocols documentation; Research; Research Personnel; Resources; Respiratory physiology; Role; Source; Sputum; United States National Institutes of Health; airway hyperresponsiveness; airway inflammation; asthmatic airway; eosinophil; volunteer

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of all of the laboratory studies conducted under this protocol is to help to determine the role of the eosinophil (allergy cell) in asthma. Our studies have indicated that the presence of the eosinophil in induced sputum (mucous) from the lungs of research volunteers with asthma is associated with airway hyperresponsiveness or the 'twitchiness' of the asthmatic airway rather than the actual decrease in lung function. The eosinophil is also becoming recognized as a cell that helps to regulate airway inflammation and is not simply a cell that moves to the lung to cause bad effects. This study will help to further research in to the complex role that eosinophils have in asthma.

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