Inner City Asthma Consortium

内城哮喘联盟的目标是实施一项长期的科学计划，以降低内城儿童哮喘的严重程度和预防哮喘，并确定这些人群哮喘的免疫发病机制。其具体目标是：1)进行临床试验，评估有希望的基于免疫的疗法在降低美国市中心少数族裔儿童哮喘严重程度和预防疾病发作方面的安全性和有效性；2)进行研究，描述作为该联盟进行的临床试验的组成部分的此类疗法的潜在机制；3)对哮喘的发病、进展和严重程度的免疫发病机制进行临床研究；以及4)开发和验证替代/生物标记物，以衡量疾病的阶段、进展和治疗效果。

The objectives of the Inner City Asthma Consortium are to implement a long range scientific plan to reduce asthma severity and prevent asthma among inner city children and to identify the mechanisms involved in the immunopathogenesis of asthma in these populations. The specific objectives are to: 1) conduct clinical trials to evaluate the safety and efficacy of promising immune based therapies in reducing asthma severity and preventing disease onset in minority children residing in inner cities in the United States; 2) conduct research to delineate the underlying mechanisms of such therapies as an integral part of the clinical trials undertaken by the Consortium; 3) conduct clinical studies on the immunopathogenesis of asthma onset, progression and severity ; and 4) develop and validate surrogate / biomarkers to measure disease stage, progression and therapeutic effect.