CHARACTERIZATION OF SUBJECTS WITH SEVERE ASTHMA

严重哮喘受试者的特征

• 批准号: 7607503
• 负责人: William W. Busse
• 金额: $ 0.01万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7607503
• 关键词: Adrenal Cortex Hormones; Adrenergic Agonists; Adult; Affect; Asthma; Australia; Breathing; Child; Chlamydophila pneumoniae; Clinical Trials Data Monitoring Committees; Computer Retrieval of Information on Scientific Projects Database; Data Coordinating Center; Disease; Europe; Funding; Grant; Health Care Costs; Healthcare Systems; Impairment; Institution; Life Style; Minority; Modality; Mycoplasma pneumoniae; North America; Patients; Population; Recruitment Activity; Research; Research Personnel; Resources; Respiratory Tract Infections; Source; United States National Institutes of Health; Virus; Woman; novel therapeutics; programs

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study is no longer recruiting subjects. Asthma affects approximately 8% of the adult population and up to 20% of children in North America, Europe, and Australia. The majority of these patients have mild-to-moderate disease, which can be controlled with inhaled corticosteroids and an inhaled short acting B-adrenergic agonist. It is, however, estimated that about 5% to 10% of asthma patients have severe disease that does not respond to usual treatment modalities, including systemic corticosteroids. This group of patients is an important subset of asthma patients. For example, they suffer the greatest impairment of their lifestyle, and their disease has a profound impact on the health-care system as they use a disproportional amount of health-care costs. Furthermore minorities and women share this burden. Finally, this aspect of asthma is poorly understood, and thus there are major limitations to new therapeutics. The NIH/NHLBI has funded a group of 8 investigators, a Data Coordinating Center (DCC), and a Data Safety Monitoring Board (DSMB) under the Acronym SARP (Severe Asthma Research Program). We believe that severe asthma may be caused, in some patients, by a persistent respiratory infections with viruses, Mycoplasma pneumoniae, or Chlamydia pneumoniae, and that this will be more common in severe disease. To evaluate this hypothesis, a severe asthma population will be identified and compared to mild-to-moderate asthma and normal controls. The primary objective of these studies will be to determine whether evidence of a persistent respiratory infections is associated with severe asthma and results in greater limitation in airflow.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 这项研究不再是招募主题。 哮喘影响着大约8％的成年人口，最多20％的儿童在北美，欧洲和澳大利亚。这些患者中的大多数患有轻度至中度疾病，可以用吸入的皮质类固醇和吸入的短作用B-肾上腺素能激动剂来控制。但是，据估计，大约5％至10％的哮喘患者患有严重疾病，对通常的治疗方式，包括全身性皮质类固醇。这组患者是哮喘患者的重要子集。例如，他们的生活方式受到最大的损害，他们的疾病对医疗保健系统产生了深远的影响，因为他们使用了不变的医疗保健费用。此外，少数民族和妇女享有这一负担。最后，哮喘的这一方面知之甚少，因此新疗法存在主要局限性。 NIH/NHLBI资助了一组由8个调查人员，一个数据协调中心（DCC）和数据安全监测委员会（DSMB）（严重哮喘研究计划）的数据安全监测委员会（DSMB）。 我们认为，在某些患者中，可能是由于病毒，支原体肺炎或肺炎衣原体的持续性呼吸道感染而引起的严重哮喘，这将在严重疾病中更常见。 为了评估这一假设，将确定严重的哮喘种群，并将其与轻度至中度哮喘和正常对照组进行比较。 这些研究的主要目的是确定持续性呼吸道感染的证据是否与严重的哮喘有关，并导致气流的限制更大。