CYTOKINE/CHEMOKINE RESPONSE IN ASTHMA EXACERBATIONS DUE TO COLDS

感冒引起的哮喘加重中的细胞因子/趋化因子反应

• 批准号: 7375511
• 负责人: William W. Busse
• 金额: $ 0.25万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7375511
• 关键词: CYTOKINE; CHEMOKINE; RESPONSE; ASTHMA; EXACERBATIONS

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Many patients with asthma have worsening of asthma symptoms when they have an upper respiratory infection (head cold). Rhinovirus (RV), a common cold virus, is frequently linked with asthma exacerbations in children and young adults. This study looks at the why some individuals with asthma have worsening of their asthma when they get a cold and other individuals do not. Is it the type of virus or is the individual's reaction to any virus that causes the worsening of asthma symptoms. Research volunteers with asthma are asked to call the research unit when they develop a cold. Research samples including nasal washings, sputum (mucous coughed up from the lungs), blood, and in some cases, when safety allows, samples of fluid and tissue from the lungs are taken during the time when cold symptoms are present and then again when cold symptoms and asthma symptoms have returned to normal. We have found that there is a trend towards an increased frequency of asthma worsening in subjects who have a cold due to RV when compared to colds caused by viruses other than RV. Studies are ongoing to determine if this trend becomes more pronounced as we study more people. This study also looks at the reason that some individuals will have worsening of asthma symptoms with an RV cold while other individuals do not. We are focusing on a protein called interferon gamma (IFNg). Previous studies have indicated that individuals who make a low level of IFNg when exposed to RV tend to have greater worsening of asthma symptoms. Measurements of IFNg will also be made in this study to see if asthma exacerbations are associated with low levels of IFNg.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。许多哮喘患者患有上呼吸道感染（头部冷）时，哮喘症状恶化。鼻病毒（RV）是一种常见的冷病毒，经常与儿童和年轻人的哮喘恶化有关。这项研究探讨了某些患有哮喘的人在感冒而其他人没有哮喘时会恶化哮喘的原因。是病毒的类型还是个人对任何导致哮喘症状恶化的病毒的反应。 患有哮喘的研究志愿者在感冒时被要求致电研究部门。研究样品包括鼻洗，痰液（粘液从肺部咳嗽），血液，在某些情况下，当安全性时，在存在冷症状的过程中，从肺部的液体和组织样本进行，然后在冷症状和哮喘症状恢复正常时再次。 我们发现，与由RV以外的病毒引起的感冒相比，由于RV的感冒而在受试者中的哮喘频率加剧的频率增加存在趋势。正在进行研究以确定随着我们研究更多的人，这种趋势是否变得更加明显。 这项研究还研究了某些人会因RV冷的哮喘症状而恶化，而其他人则不会恶化哮喘症状。我们专注于一种称为干扰素伽玛（IFNG）的蛋白质。先前的研究表明，暴露于RV时的IFNG水平较低的个体往往会更恶化哮喘症状。在本研究中也将进行IFNG的测量，以查看哮喘的恶化是否与IFNG水平较低有关。