CYTOKINE/CHEMOKINE RESPONSE IN ASTHMA EXACERBATIONS DUE TO COLDS

感冒引起的哮喘加重中的细胞因子/趋化因子反应

基本信息

  • 批准号:
    7375511
  • 负责人:
  • 金额:
    $ 0.25万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2005
  • 资助国家:
    美国
  • 起止时间:
    2005-12-01 至 2006-11-30
  • 项目状态:
    已结题

项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Many patients with asthma have worsening of asthma symptoms when they have an upper respiratory infection (head cold). Rhinovirus (RV), a common cold virus, is frequently linked with asthma exacerbations in children and young adults. This study looks at the why some individuals with asthma have worsening of their asthma when they get a cold and other individuals do not. Is it the type of virus or is the individual's reaction to any virus that causes the worsening of asthma symptoms. Research volunteers with asthma are asked to call the research unit when they develop a cold. Research samples including nasal washings, sputum (mucous coughed up from the lungs), blood, and in some cases, when safety allows, samples of fluid and tissue from the lungs are taken during the time when cold symptoms are present and then again when cold symptoms and asthma symptoms have returned to normal. We have found that there is a trend towards an increased frequency of asthma worsening in subjects who have a cold due to RV when compared to colds caused by viruses other than RV. Studies are ongoing to determine if this trend becomes more pronounced as we study more people. This study also looks at the reason that some individuals will have worsening of asthma symptoms with an RV cold while other individuals do not. We are focusing on a protein called interferon gamma (IFNg). Previous studies have indicated that individuals who make a low level of IFNg when exposed to RV tend to have greater worsening of asthma symptoms. Measurements of IFNg will also be made in this study to see if asthma exacerbations are associated with low levels of IFNg.
本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者(PI)可能已经从另一个NIH来源获得了主要资金,因此可以在其他CRISP条目中表示。列出的机构是中心的,不一定是研究者的机构。许多哮喘患者在上呼吸道感染(头感冒)时,哮喘症状会恶化。鼻病毒(RV)是一种常见的感冒病毒,经常与儿童和年轻人的哮喘加重有关。这项研究着眼于为什么一些哮喘患者在感冒时哮喘会恶化,而另一些人则不会。是病毒的类型还是个体对任何病毒的反应导致哮喘症状恶化?患有哮喘的研究志愿者被要求在感冒时给研究单位打电话。研究样本包括洗鼻液、痰液(从肺部咳出的粘液)、血液,在某些情况下,在安全允许的情况下,在出现感冒症状时采集肺部的液体和组织样本,然后在感冒症状和哮喘症状恢复正常时再次采集。我们发现,与RV以外的病毒引起的感冒相比,RV引起的感冒患者哮喘恶化的频率有增加的趋势。研究正在进行中,以确定随着我们研究的人越来越多,这种趋势是否会变得更加明显。这项研究还探讨了一些人因RV感冒而哮喘症状恶化的原因,而另一些人则没有。我们正专注于一种叫做干扰素(IFNg)的蛋白质。先前的研究表明,暴露于RV时产生低水平IFNg的个体往往有更严重的哮喘症状恶化。本研究还将测量IFNg,以确定哮喘恶化是否与低水平的IFNg有关。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

William W. Busse其他文献

A Função dos Modificadores dos Leucotrienos no tratamento da Asma
阿斯玛白三烯的修改功能
  • DOI:
  • 发表时间:
    1998
  • 期刊:
  • 影响因子:
    0
  • 作者:
    J. Randy;Kelly A. McGill;William W. Busse
  • 通讯作者:
    William W. Busse
Abnormal degradation of macroaggregated albumin particles in patients with asthma
  • DOI:
    10.1016/0091-6749(74)90105-5
  • 发表时间:
    1974-05-01
  • 期刊:
  • 影响因子:
  • 作者:
    William W. Busse;Charles E. Reed
  • 通讯作者:
    Charles E. Reed
Epidermal adenyl cyclase of human and mouse: A study of the atopic state
  • DOI:
    10.1016/0091-6749(74)90107-9
  • 发表时间:
    1974-05-01
  • 期刊:
  • 影响因子:
  • 作者:
    Tee-Ping Lee;William W. Busse;Charles E. Reed
  • 通讯作者:
    Charles E. Reed
Efficacy of montelukast during the allergy season in patients with chronic asthma and seasonal aeroallergen sensitivity
  • DOI:
    10.1016/s1081-1206(10)61041-1
  • 发表时间:
    2006-01-01
  • 期刊:
  • 影响因子:
  • 作者:
    William W. Busse;Thomas B. Casale;Mark S. Dykewicz;Eli O. Meltzer;Steven R. Bird;Carolyn M. Hustad;Evalyn Grant;Robert K. Zeldin;Jonathan M. Edelman
  • 通讯作者:
    Jonathan M. Edelman
2023 CSACI annual scientific meeting book of abstracts
2023年CSACI年度科学会议摘要集
  • DOI:
    10.1186/s13223-023-00866-4
  • 发表时间:
    2024
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Canada Ottowa;Felix Chan;Victor Nguyen;Susan Tarlo;Mariam Eldaba;Hoang Pham;William W. Busse;Monica Kraft;Christian Domingo;Ines de Mir;Diego Maselli;Changming Xia;N. Pandit;Xavier Soler;J. Jacob;Harry Sacks;P. Rowe;Sven Sorensen;Y. Deniz;Danielle Ben‑Shoshan;Mariah Rodriguez‑Imbarlina;J. Protudjer;Alexander Singer;Elissa M Abrams;Alan Kaplan;S. Waserman;Douglas P. Mack;R. Hauptman;Anne Ellis;Lauren Mack;Spiro Photopolous;Juan C. Ruiz;Phillipe Begin;Taft Micks;Harold Kim;S. Linton;L. Hossenbaccus;Mya Gillberry;Jenny Thiele;L. Steacy;L. Bacharier;T. Guilbert;Monika Gappa;S. Dell;Nikolaos G. Papadopoulos;A. Deschildre;A. Custovic;Arman Altincatal;O. Ledanois;R. Gall;Anju T. Peters;A. Côté;Xavier Muñoz;S. Nash;Megan Hardin;Lucía de Prado Gómez;Reewa Kafle;Nami P. Shrestha;Yingqi Wu;Harissios Marc Duchesne;E. Volfson;Aswathi Nair;Alex Huynh;K. Son;Kayla Zhang;C. Venegas;K. Radford;S. Svenningsen;Parameswaran Nair;M. Mukherjee;Manitoba Michael A Winnipeg;Golding;Jennifer L. P. Protudjer;Michael A. Golding;L. Connors;Jasmin Lidington;Elizabeth Magaji;Rebecca Kim;Jennifer L. P. Protudjer;Brock A. Williams;S. Erdle;Andrea Grantham;R. Khadaroo;L. Soller;Edmond S Chan;Jo;S. Filuk;Lenore Johnstone;Nancy Ross;Janice Skoleski;Loewen Keeley;Shannon Deane;Elinor Simons;L. Perlman;Sofianne Gabrielli;Annabel Clarke;Luca Delli Colli;Marina Delli Colli;Judy Morris;Jocelyn Gravel;Rod Lim;Ran D. Goldman;Andrew O’Keefe;J. Gerdts;Derek K. Chu;J. Upton;E. Hochstadter;Jocelyn Moisan;A. Bretholz;C. Mccusker;Xun Zhang;M. Ben;Karen Dobbin;Simonne L. Horwitz;Adnan Al Ali;Danbing Ke;L. Beaudette;E. Grunebaum;C. Piccirillo;Casey Cohen;Bruce Mazer;Abigail Brodovitch;Adnan Al;Pasquale Mulé;Victor Paradis;A. Roches;Charles Elbany;Camille Braun;François Graham;K. Samaan;R. Labrosse;L. Paradis;P. Bégin;Montréal QC CHU Sainte‑Justine;Sean Duke;James Maiarana;Pariya Yousefi;Samantha Gerrie;Cornelius F. Boerkoel;A. Amid;Dewi Schrader;Orlee Guttman;Sally Lawrence;Meera Rayar;Connie Yang;Anna F Lee;A. Kanani;Persia Pourshahnazari;Audi Setiadi;Jacob Rozmus;K. Hildebrand;Elliot James;S. Turvey;Janet G Markle;Catherine M. Biggs;Jana Abi;J. Campisi;Raham Rahgoshai;Nicholas Vonniessen;Peter Goldberg;Salman T. Qureshi;Parinaz Tavakoli Zaniani;Eisha A. Ahmed;Nicholas Vonneissen;Wei Zhao;O. Lepeshkina;Geneviève Solomon;Katarzyna Farrell;Sarah M. McAlpine;Alejandro Palma;Vitoria Murakami Olyntho;Jake Colautti;Manel Jordana;Doron Sommer;J. Koenig;Vitoria Murakami;Olyntho—CSACI Summer Studentship;Abdulrahman Ahmad Al Ghamdi;Stephen Betschel;Joanne Wang;Gofrey Lam;Raymond H. Mak;Samina Nazarali;Beata Derfalvi;Pascale Clark;M. Masse;A. Copaescu;J. Trubiano;Bryan C. Ng;Deborah LeBlanc;S. Cameron;Victoria E Cook;Moss A. Bruton;Anthony Cusano;Michelle Kwok;G. Isabwe;Joshua V. Yu;Ashley Holmes;Cindy Srinivasan;Jack Borle;Bruce Ritchie;A. Adatia
  • 通讯作者:
    A. Adatia

William W. Busse的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('William W. Busse', 18)}}的其他基金

Inner City Asthma consortium 3 (ICAC3)
内城哮喘协会 3 (ICAC3)
  • 批准号:
    9110805
  • 财政年份:
    2014
  • 资助金额:
    $ 0.25万
  • 项目类别:
Inner City Asthma consortium 3 (ICAC3)
内城哮喘协会 3 (ICAC3)
  • 批准号:
    8903803
  • 财政年份:
    2014
  • 资助金额:
    $ 0.25万
  • 项目类别:
Inner City Asthma Consortium
内城哮喘协会
  • 批准号:
    8938738
  • 财政年份:
    2009
  • 资助金额:
    $ 0.25万
  • 项目类别:
INNER CITY ASTHMA CONSORTIUM
内城哮喘协会
  • 批准号:
    7952351
  • 财政年份:
    2009
  • 资助金额:
    $ 0.25万
  • 项目类别:
CHARACTERIZATION OF SUBJECTS WITH SEVERE ASTHMA
严重哮喘受试者的特征
  • 批准号:
    7607503
  • 财政年份:
    2006
  • 资助金额:
    $ 0.25万
  • 项目类别:
FUNCTIONAL ACTIVITY OF AIRWAY EOSINOPHILS IN ALLERGIC DISEASE
过敏性疾病中气道嗜酸性粒细胞的功能活性
  • 批准号:
    7607564
  • 财政年份:
    2006
  • 资助金额:
    $ 0.25万
  • 项目类别:
ROLE AND CONTRIBUTION OF EOSINOPHILS TO THE PATHOGENESIS OF ASTHMA
嗜酸性粒细胞在哮喘发病中的作用和贡献
  • 批准号:
    7204336
  • 财政年份:
    2005
  • 资助金额:
    $ 0.25万
  • 项目类别:
CHARACTERIZATION OF SUBJECTS WITH SEVERE ASTHMA
严重哮喘受试者的特征
  • 批准号:
    7204361
  • 财政年份:
    2005
  • 资助金额:
    $ 0.25万
  • 项目类别:
FUNCTIONAL ACTIVITY OF AIRWAY EOSINOPHILS IN ALLERGIC DISEASE
过敏性疾病中气道嗜酸性粒细胞的功能活性
  • 批准号:
    7375557
  • 财政年份:
    2005
  • 资助金额:
    $ 0.25万
  • 项目类别:
CYTOKINE/CHEMOKINE RESPONSE IN ASTHMA EXACERBATIONS DUE TO COLDS
感冒引起的哮喘加重中的细胞因子/趋化因子反应
  • 批准号:
    7204369
  • 财政年份:
    2005
  • 资助金额:
    $ 0.25万
  • 项目类别:

相似国自然基金

Chemokine-Gli2信号环路调控肝癌生长的分子机制及其靶点价值
  • 批准号:
    81660467
  • 批准年份:
    2016
  • 资助金额:
    39.0 万元
  • 项目类别:
    地区科学基金项目

相似海外基金

Cytomegalovirus-based vaccine vectors - the role of cytomegalovirus gH/gL/chemokine glycoprotein complexes in the vector-induced immune response
基于巨细胞病毒的疫苗载体 - 巨细胞病毒 gH/gL/趋化因子糖蛋白复合物在载体诱导的免疫反应中的作用
  • 批准号:
    268258952
  • 财政年份:
    2015
  • 资助金额:
    $ 0.25万
  • 项目类别:
    Research Grants
Regulation of the anti-tumour immune response by the chemokine decoy receptor CCX-CKR
趋化因子诱饵受体 CCX-CKR 调节抗肿瘤免疫反应
  • 批准号:
    nhmrc : 1030247
  • 财政年份:
    2012
  • 资助金额:
    $ 0.25万
  • 项目类别:
    NHMRC Project Grants
Absence of CC chemokine receptor 6 dysregulates the humoral immune response.
CC 趋化因子受体 6 的缺失会导致体液免疫反应失调。
  • 批准号:
    nhmrc : 1004592
  • 财政年份:
    2011
  • 资助金额:
    $ 0.25万
  • 项目类别:
    Project Grants
Regulation of the adaptive immune response by chemokine scavenging receptors
趋化因子清除受体调节适应性免疫反应
  • 批准号:
    G0901113/1
  • 财政年份:
    2010
  • 资助金额:
    $ 0.25万
  • 项目类别:
    Research Grant
Toll like receptors and chemokine receptors: 2 interconnected arms of the innate immune response.
Toll 样受体和趋化因子受体:先天免疫反应的两个相互关联的分支。
  • 批准号:
    G0700120/1
  • 财政年份:
    2008
  • 资助金额:
    $ 0.25万
  • 项目类别:
    Research Grant
In situ tissue regeneration - chemokine triggered cellular and molecular response of human mesenchymal stem cells
原位组织再生-趋化因子触发人间充质干细胞的细胞和分子反应
  • 批准号:
    72148255
  • 财政年份:
    2008
  • 资助金额:
    $ 0.25万
  • 项目类别:
    Research Grants
CYTOKINE/CHEMOKINE RESPONSE IN ASTHMA EXACERBATIONS DUE TO COLDS
感冒引起的哮喘加重中的细胞因子/趋化因子反应
  • 批准号:
    7204369
  • 财政年份:
    2005
  • 资助金额:
    $ 0.25万
  • 项目类别:
Cytokine/Chemokine Response in Asthma Exacerbations Due to Colds
感冒引起的哮喘加重中的细胞因子/趋化因子反应
  • 批准号:
    7043922
  • 财政年份:
    2003
  • 资助金额:
    $ 0.25万
  • 项目类别:
Chemokine response in B cell development and function
B 细胞发育和功能中的趋化因子反应
  • 批准号:
    6843138
  • 财政年份:
    2002
  • 资助金额:
    $ 0.25万
  • 项目类别:
Chemokine response in B cell development and function
B 细胞发育和功能中的趋化因子反应
  • 批准号:
    6697475
  • 财政年份:
    2002
  • 资助金额:
    $ 0.25万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了