GENERAL CLINICAL RESEARCH CENTER

全科临床研究中心

• 批准号: 7225235
• 负责人: PETER L SLAVIN
• 金额: $ 474.44万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1978
• 资助国家: 美国
• 起止时间: 1978-02-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7225235
• 关键词: GENERAL; CLINICAL; RESEARCH; CENTER

EXCEED THE SPACE PROVIDED. This five year competitive renewal proposes the continuing funding of the Mallinckrodt GCRC at Massachusetts General Hospital. The Clinical Research Center has provided continuous support for MGH investigators performing human research since 1921,with support from NCRR as a GCRC since 1978.In the previous 5 years, the GCRC has supported 190 protocols conducted by more than 200 investigators in the Departments of Medicine, Neurology, Psychiatry, Pediatrics, Orthopedics, Anesthesia, Radiology, and Surgery. The current proposal continues the wide-spread support for clinical investigation at the MGH, including 119 protocols with the majority (95%)performed by NIH supported investigators. The proposed studies include research in metabolism, neuroendocrinology, reproductive physiology and disorders of the hypothalamic-pituitary-gonadal axis, HIV, diabetes including islet transplantation, psychiatric disorders including schizophrenia, addiction, obsessive compulsive disorders and anorexia, neurologic disorders such as Huntington's disease, Alzheimer's disease and amyotrophic lateral sclerosis, and the neurologic effects of general anesthesia, among others. In addition to the established Bionutrition, Biostatistics and Bioinformatics, and Clinical Laboratory Cores, we propose a new Biomedical Imaging Core that is designed to support the increasing number of MGH and MIT investigators using NMR, PET scanning, and other imaging modalities in human research. Thirty six protocols from 26 investigators in Radiology,Anesthesia, Medicine, Psychiatry, and Neurology that will use this core are included. A formal program of education for investigators, research nurses and dietitians, medical and pre-med students remains a strong component of the current application. Currently, nine CAP or K-23 awardees are included in the grant proposal. A satellite GCRC, located at the Massachusetts Institute of Technology and which has been increasingly integrated into the MGH GCRC activities during the previous 3 years, is included in this proposal. The satellite proposal, structured as a subcontract to the MGH, includes 48 protocols that are conducted in their entirety at MIT or at both GCRCs. The collaboration between the MGH GCRC and MIT satellite extends across all aspects of the GCRC includingjoint administration, shared resources, such as the Bionutrition, Biostatistics, and Imaging Cores, and joint training to expand the research resources at both institutions and facilitate the seamless

超出所提供的空间。 这一为期五年的竞争性续约建议继续为Mallinckrodt GCRC提供资金， 马萨诸塞州综合医院。临床研究中心为MGH提供了持续的支持 自1978年以来，NCRR一直作为GCRC提供支持。 在过去的5年里，GCRC支持了200多名研究人员进行的190项方案， 内科、神经科、精神科、儿科、骨科、麻醉科、放射科， 手术目前的提案继续广泛支持MGH的临床研究， 包括119个方案，其中大多数（95%）由NIH支持的研究人员执行。拟议 研究包括新陈代谢、神经内分泌学、生殖生理学和生殖系统疾病的研究 下丘脑-垂体-性腺轴、HIV、糖尿病（包括胰岛移植）、精神疾病 包括精神分裂症、成瘾、强迫症和厌食症、神经系统疾病， 如亨廷顿氏病、阿尔茨海默氏病和肌萎缩侧索硬化症， 全身麻醉，等等除了已建立的生物营养学、生物统计学和 生物信息学和临床实验室核心，我们提出了一个新的生物医学成像核心， 支持越来越多的MGH和MIT研究人员使用NMR，PET扫描和其他 人类研究中的成像模式。来自放射学、麻醉学、 医学，精神病学和神经病学，将使用这个核心包括在内。一个正规的教育计划， 研究人员，研究护士和营养师，医学和医学预科生仍然是一个强大的组成部分， 目前的应用。目前，9名CAP或K-23获奖者被列入赠款提案。 位于马萨诸塞州理工学院的卫星GCRC， 在过去3年中纳入MGH GCRC活动中的信息包括在本提案中。的 卫星计划是对MGH的补充，包括48项协议， 在麻省理工学院或在两个GCRC。MGH GCRC和MIT卫星之间的合作扩展了 在GCRC的所有方面，包括联合管理，共享资源，如生物营养素， 生物统计学和成像核心，以及联合培训，以扩大两个机构的研究资源， 方便无缝