EXTRAMURAL RESEARCH FACILITIES CONSTRUCTION

校外研究设施建设

• 批准号: 6829187
• 负责人: PETER L SLAVIN
• 金额: $ 271.07万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-30 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6829187
• 关键词: EXTRAMURAL; RESEARCH; FACILITIES; CONSTRUCTION

DESCRIPTION (provided by applicant): The Massachusetts General Hospital (MGH, Boston, MA) proposes to renovate and expand a swine research facility to accommodate its long-standing research program in transplantation biology involving inbred miniature swine (IMS). MGH currently receives more than $6.3 million annually in federal research support for 4 program projects and 7 research projects involving organ, bone marrow and pancreatic islet cell transplantation, xenotransplantation, immunosuppression, induced transplantation tolerance and molecular immunology. These animals currently are housed under a contractual agreement with a commercial animal facility at a different site in central Massachusetts, but this facility no longer meets current and projected needs of the scientists at MGH and other institutions who rely on these animals and/or their tissues. The proposed facility will provide approximately 20,000 sq ft of space for animal reproduction and housing, sterile tissue and organ harvest, transplantation surgery and tissue and organ preservation. This facility will enable the expansion of the colony from 425 animals to approximately 600 animals in accordance with current ILAR Guide standards and will allow us to conduct sterile procedures on site rather than transport animals twice a week from the current animal facility to our laboratory in Boston. It will allow our highly trained research and animal services staff to assume full control over the breeding and care of these valuable inbred lines rather than contract for animal care with another organization, and it will assure long-term access to the proposed site, which the current facility cannot assure. We anticipate that this advantage will accelerate the progress of our ongoing research and allow us to move into a new translational stage of our work in a representative large-animal model before proceeding to clinical studies.

描述（由申请人提供）： 马萨诸塞州总医院（MGH，Boston，MA）建议翻新和扩建一个猪研究设施，以适应其涉及近交系小型猪（IMS）的移植生物学长期研究计划。MGH目前每年获得超过630万美元的联邦研究支持，用于4个计划项目和7个研究项目，涉及器官，骨髓和胰岛细胞移植，异种移植，免疫抑制，诱导移植耐受和分子免疫学。这些动物目前根据与马萨诸塞州中部不同地点的商业动物设施的合同协议圈养，但该设施不再满足MGH和依赖这些动物和/或其组织的其他机构的科学家的当前和预计需求。 拟议的设施将提供约20，000平方英尺的空间，用于动物繁殖和住房，无菌组织和器官采集，移植手术以及组织和器官保存。 根据现行ILAR指南标准，该设施将使殖民地从425只动物扩大到约600只动物，并使我们能够在现场进行无菌程序，而不是每周两次将动物从当前动物设施运送到我们在波士顿的实验室。它将使我们训练有素的研究和动物服务人员能够完全控制这些宝贵的近交系的育种和护理，而不是与另一个组织签订动物护理合同，它将确保长期进入拟议的地点，目前的设施无法保证。我们预计，这一优势将加速我们正在进行的研究的进展，并使我们能够在进行临床研究之前，在代表性的大型动物模型中进入新的转化阶段。

项目成果

Assessing the effect of immunosuppression on engraftment of pancreatic islets.

评估免疫抑制对胰岛植入的影响。

• DOI: 10.1097/tp.0b013e31829f7515
• 发表时间: 2013
• 期刊: Transplantation
• 影响因子: 6.2
• 作者: Vallabhajosyula,Prashanth;Hirakata,Atsushi;Shimizu,Akira;Okumi,Masayoshi;Tchipashvili,Vaja;Hong,Hanzhou;Yamada,Kazuhiko;Sachs,DavidH
• 通讯作者: Sachs,DavidH

Vascularized composite allograft tolerance across MHC barriers in a large animal model.

• DOI: 10.1111/ajt.12560
• 发表时间: 2014-02
• 期刊: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
• 作者: Leonard DA;Kurtz JM;Mallard C;Albritton A;Duran-Struuck R;Farkash EA;Crepeau R;Matar A;Horner BM;Randolph MA;Sachs DH;Huang CA;Cetrulo CL Jr
• 通讯作者: Cetrulo CL Jr

Non-invasive monitoring of skin inflammation using an oxygen-sensing paint-on bandage.

• DOI: 10.1364/boe.8.004640
• 发表时间: 2017-10
• 期刊: Biomedical optics express
• 影响因子: 3.4
• 作者: Zongxi Li;N. Navarro-Alvarez;E. J. Keeley;Nicholas H. Nowell;Beatriz M M Gonçalves-Beatriz-M-M-Gonçalves-39693886;Christene A. Huang;C. Evans

Miniature Swine as a Clinically Relevant Model of Graft-Versus-Host Disease.

• 发表时间: 2015-10
• 期刊: Comparative medicine
• 影响因子: 0.8
• 作者: R. Duran‐Struuck;Christene A. Huang;Katherine Orf;R. Bronson;D. Sachs;T. Spitzer

Adoptive Transfer of Renal Allograft Tolerance in a Large Animal Model.

• DOI: 10.1111/ajt.13424
• 发表时间: 2016-01
• 期刊: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
• 作者: Villani V;Yamada K;Scalea JR;Gillon BC;Arn JS;Sekijima M;Tasaki M;Cormack TA;Moran SG;Torabi R;Shimizu A;Sachs DH
• 通讯作者: Sachs DH