ENHANCEMENT OF HUMORAL IMMUNE RESPONSES BY CD1D-RESTRICTED NKT CELLS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 我们准备了解NKT增强的抗体应答是否需要B细胞和/或DC表达CD1d。这是了解CD1d限制的NKT细胞增强抗体反应的机制的关键的第一步。我们的发现将指导AIM 2的实验，并可能指导未来的疫苗策略。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We are poised to understand if CD1d expression by B cells and/or DCs is required for NKT-enhanced Ab responses. This is a critical first step in understanding the mechanisms by which CD1d-restricted NKT cells enhance Ab responses. Our findings will direct the experiments in Aim 2 and may guide future vaccine strategies.