Novel Antibacterial Fluoride-releasing Dental Materials

新型抗菌释氟牙科材料

• 批准号: 7653431
• 负责人: XIAOMING XU
• 金额: $ 35.16万
• 依托单位: LSU HEALTH SCIENCES CENTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-03-01 至 2013-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7653431
• 关键词: Accounting; Adhesives; Adopted; Animals; Anti-Bacterial Agents; Area; Bacteria; Caries prevention; Child; Clinical Trials; Complex; Compomers; Composite Dental Resin; Dental; Dental Bonding; Dental Enamel; Dental Materials; Dental caries; Dentists; Development; Diabetes Mellitus; Drug Formulations; Economics; Elderly; Extravasation; Filler; Fluorides; Fright; Future; Generations; Glass; Goals; Growth; Head and neck structure; Healthcare; Human; In Vitro; Investigation; Lactic acid; Lactobacillus casei; Lead; Lesion; Longevity; Lysine; Mechanics; Microbial Biofilms; Modeling; Oral health; Patients; Pharmaceutical Preparations; Physically Challenged; Plant Resins; Population; Property; Quality of life; Recurrence; Risk; Series; Sjogren' s Syndrome; Streptococcus mutans; Structure; Sucrose; Syndrome; System; Testing; Tooth structure; Vulnerable Populations; Xerostomia; Zirconium; ammonium fluoride; antimicrobial; base; biomaterial compatibility; calcium phosphate; diabetic; high risk; improved; irradiation; microleakage; monomer; novel; pandemic disease; prevent; remineralization; restoration; restorative material; scale up; seal; zirconium oxide

DESCRIPTION (provided by applicant): We propose to investigate and develop novel dental materials that are antibacterial and/or fluoride-releasing and act synergistically to form a highly effective caries-inhibition restorative system. Such materials are expected to have an enormous impact on the oral health of the most vulnerable, high caries-risk, portion of the population: the medically-compromised who suffer from xerostomia or dry mouth (due to Sjvgren's syndrome, diabetes, head and neck irradiation, and medications), children, the elderly, and low socio-economic groups. Dental caries continues to be a worldwide pandemic disease. While resin-based dental composites (RBC) are widely used to restore carious teeth, secondary (recurrent) caries remains the leading cause cited for their replacement. Thus, much effort has been directed towards development of composites that release caries-preventing agents such as fluoride. Nevertheless, current dental composites are deficient in both fluoride-release and fluoride-recharge capabilities, and very few have antimicrobial or other capabilities for preventing plaque. Furthermore, all dental composites and compomers require bonding agents in order to reduce marginal leakage and limit secondary caries. Yet, both non-fluoride-releasing and low-fluoride-releasing bonding agents are inherently barriers to the transport of fluoride to caries-prone areas. Another problem is that the majority of self-etching dental bonding agents are susceptible to hydrolytical degradation, which leads to eventual leakage, secondary caries and reduced RBC lifetime. On the primary caries prevention front, sealants, including fluoride-releasing sealants, have shown caries-prevention efficacy, yet the dental profession has been slow to adopt sealants due, in part, to the fear that caries will continue to progress under sealed pits and fissures. The goal of this project is to develop novel monomers with enhanced antibacterial activity, enhanced fluoride release and recharge, and other capabilities, and combine them with fluoride-releasing fillers and bioactive fillers to overcome the multiple problems associated with current composites, adhesives and sealants that limit their caries-inhibition efficacy and restoration longevity. This project has four specific aims: (1) to formulate and optimize a novel antibacterial fluoride releasing dental composite, (2) to formulate and optimize a novel hydrolytically stable fluoride-releasing dental bonding agent, (3) to formulate and characterize a novel antibacterial bioactive sealant that releases calcium, phosphate, and fluoride, (4) to test the overall caries-inhibition efficacy of the novel anticariogenic dental material system by artificial caries models. The hypotheses are: (1) Dental materials containing the new fluoride exchange monomers will have enhanced fluoride release and recharge capabilities while maintaining adequate or improved physical and mechanical properties. (2) The combination of antimicrobial activity with enhanced remineralization capability will synergistically lead to significantly higher caries-inhibiting efficacy of the restorative materials. (3) The combined use of an antibacterial fluoride-releasing composite, bonding agent and bioactive sealant will further reduce caries. This project seeks to develop a series of antibacterial, fluoride-releasing, and bioactive dental materials. These materials are expected to have enhanced anti-caries efficacy over existing resin-based dental materials. The development of these materials has the potential to make a huge impact on oral health care and oral health quality-of-life, in particular for the vast number of high-caries-risk patients (medically compromised who suffer from xerostomia or dry mouth, children, elderly, mentally or physically challenged).

描述（由申请人提供）：我们建议研究和开发抗菌和/或释放氟化物的新型牙科材料，并协同作用以形成高效的防龋修复系统。预计此类材料将对最脆弱、高龋齿风险的部分人群的口腔健康产生巨大影响：患有口干症或口干症（由于干燥综合征、糖尿病、头颈照射和药物引起）的医学缺陷者、儿童、老年人和社会经济地位较低的群体。龋齿仍然是一种世界性的流行病。虽然树脂基牙科复合材料 (RBC) 广泛用于修复龋齿，但继发性（复发性）龋齿仍然是替代材料的主要原因。因此，人们付出了很多努力来开发释放防龋剂（例如氟化物）的复合材料。然而，目前的牙科复合材料缺乏氟化物释放和氟化物补充能力，并且很少有抗菌或其他防止牙菌斑的能力。此外，所有牙科复合材料和复合体都需要粘合剂，以减少边缘渗漏并限制继发龋。然而，不释放氟化物和低氟化物释放的粘合剂本质上都是氟化物向龋齿易发区域输送的障碍。另一个问题是，大多数自酸蚀牙科粘合剂容易水解降解，从而导致最终渗漏、继发龋齿和红细胞寿命缩短。在初级防龋方面，封闭剂（包括释放氟化物的封闭剂）已显示出防龋功效，但牙科行业在采用封闭剂方面进展缓慢，部分原因是担心龋齿会在封闭的窝沟和裂隙下继续发展。该项目的目标是开发具有增强抗菌活性、增强氟化物释放和补给等功能的新型单体，并将其与氟化物释放填料和生物活性填料相结合，以克服与当前复合材料、粘合剂和密封剂相关的多重问题，这些问题限制了其防龋功效和修复寿命。该项目有四个具体目标：(1) 配制和优化新型抗菌释氟牙科复合材料，(2) 配制和优化新型水解稳定释氟牙科粘合剂，(3) 配制和表征一种可释放钙、磷酸盐和氟化物的新型抗菌生物活性封闭剂，(4) 测试总体防龋功效 通过人工龋齿模型研究新型防龋牙科材料系统。假设是：（1）含有新型氟化物交换单体的牙科材料将具有增强的氟化物释放和补充能力，同时保持足够或改进的物理和机械性能。 (2)抗菌活性与增强的再矿化能力的结合将协同导致修复材料的防龋功效显着提高。 (3)抗菌释氟复合材料、粘结剂和生物活性封闭剂的联合使用将进一步减少龋齿。该项目旨在开发一系列抗菌、释放氟化物和生物活性的牙科材料。预计这些材料比现有的树脂基牙科材料具有更强的防龋功效。这些材料的开发有可能对口腔保健和口腔健康生活质量产生巨大影响，特别是对于广大高龋风险患者（患有口干症或口干症的医疗受损患者、儿童、老年人、精神或身体障碍者）。