Novel Antibacterial Fluoride-releasing Dental Materials

项目描述/摘要 我们建议研究和开发新的牙科材料，抗菌和/或氟化物- 释放并协同作用，形成高效的防龋修复剂 系统预计这些材料将对大多数人的口腔健康产生巨大影响。 脆弱的，高龋齿风险的，人口的一部分：医疗妥协谁遭受 口干或口干（由于干燥综合征、糖尿病、头颈部照射，以及 药物），儿童，老年人和低社会经济群体。龋齿仍然是一个 世界性的流行病。虽然树脂基牙科复合材料（RBC）被广泛用于修复 龋齿、继发性（复发性）龋齿仍然是替换它们的主要原因。因此，在本发明中， 许多努力都致力于开发释放防龋剂的复合物 例如氟化物。然而，目前的牙科复合材料在氟化物释放和氟化物释放方面都存在不足。 但是，具有再充电能力的细菌很少，并且很少具有抗微生物或其他预防牙菌斑的能力。 此外，所有牙科复合材料和复合体都需要粘合剂，以减少边缘磨损。 并限制继发龋。然而，无论是非氟释放和低氟释放粘结， 试剂本身是氟化物向易患龋齿地区运输的屏障。另一个问题是 大多数自酸蚀牙科粘合剂易于水解降解，这导致 最终渗漏、继发龋和RBC寿命缩短。在基层预防龋齿方面， 密封剂，包括释放氟化物的密封剂，已经显示出预防龋齿的功效， 由于部分担心龋齿会继续发展， 在密封的坑和裂缝下 该项目的目标是开发具有增强的抗菌活性的新型单体， 氟化物释放和再充电，以及其他能力，并将它们与氟化物释放填料结合， 生物活性填料以克服与目前的复合材料、粘合剂 密封剂，限制其龋齿抑制功效和恢复寿命。该项目有四个具体 目的：（1）制备并优化一种新型抗菌释氟牙科复合材料;（2）制备并 优化新型水解稳定的氟化物释放牙科粘合剂，（3）配制和表征 释放钙、磷酸盐和氟化物的新型抗菌生物活性密封剂，（4）测试整体 通过人工龋模型研究新型防龋牙科材料体系的防龋效果。的 假设是：（1）含有新的氟交换单体的牙科材料将增强 氟化物释放和再充电能力，同时保持足够或改善的物理和机械性能， 特性. (2)抗微生物活性与增强的微生物化能力的组合将 协同地导致修复材料的显著更高的龋齿抑制功效。(3)的 抗菌氟化物释放复合物、粘合剂和生物活性密封剂的组合使用将 进一步减少龋齿。

Project Description/Abstract We propose to investigate and develop novel dental materials that are antibacterial and/or fluoride- releasing and act synergistically to form a highly effective caries-inhibition restorative system. Such materials are expected to have an enormous impact on the oral health of the most vulnerable, high caries-risk, portion of the population: the medically-compromised who suffer from xerostomia or dry mouth (due to Sj¿gren's syndrome, diabetes, head and neck irradiation, and medications), children, the elderly, and low socio-economic groups. Dental caries continues to be a worldwide pandemic disease. While resin-based dental composites (RBC) are widely used to restore carious teeth, secondary (recurrent) caries remains the leading cause cited for their replacement. Thus, much effort has been directed towards development of composites that release caries-preventing agents such as fluoride. Nevertheless, current dental composites are deficient in both fluoride-release and fluoride- recharge capabilities, and very few have antimicrobial or other capabilities for preventing plaque. Furthermore, all dental composites and compomers require bonding agents in order to reduce marginal leakage and limit secondary caries. Yet, both non-fluoride-releasing and low-fluoride-releasing bonding agents are inherently barriers to the transport of fluoride to caries-prone areas. Another problem is that the majority of self-etching dental bonding agents are susceptible to hydrolytical degradation, which leads to eventual leakage, secondary caries and reduced RBC lifetime. On the primary caries prevention front, sealants, including fluoride-releasing sealants, have shown caries-prevention efficacy, yet the dental profession has been slow to adopt sealants due, in part, to the fear that caries will continue to progress under sealed pits and fissures. The goal of this project is to develop novel monomers with enhanced antibacterial activity, enhanced fluoride release and recharge, and other capabilities, and combine them with fluoride-releasing fillers and bioactive fillers to overcome the multiple problems associated with current composites, adhesives and sealants that limit their caries-inhibition efficacy and restoration longevity. This project has four specific aims: (1) to formulate and optimize a novel antibacterial fluoride releasing dental composite, (2) to formulate and optimize a novel hydrolytically stable fluoride-releasing dental bonding agent, (3) to formulate and characterize a novel antibacterial bioactive sealant that releases calcium, phosphate, and fluoride, (4) to test the overall caries-inhibition efficacy of the novel anticariogenic dental material system by artificial caries models. The hypotheses are: (1) Dental materials containing the new fluoride exchange monomers will have enhanced fluoride release and recharge capabilities while maintaining adequate or improved physical and mechanical properties. (2) The combination of antimicrobial activity with enhanced remineralization capability will synergistically lead to significantly higher caries-inhibiting efficacy of the restorative materials. (3) The combined use of an antibacterial fluoride-releasing composite, bonding agent and bioactive sealant will further reduce caries.