LSU DENTAL COBRE: DEVELOPMENT OF NEW ADHESIVE FLOURIDE-RELEASING MONOMERS

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。复发性龋齿是牙齿修复失败最常见的原因。释放氟化物的修复材料可以减少修复体边缘的复发性龋病。然而，目前的牙科复合材料和复合材料的氟化物释放和补充能力较低，它们需要粘合剂粘合到牙齿结构上。目前的牙粘接剂也几乎没有释放和再充电的能力，并形成阻碍氟化物运输的屏障。封闭剂已被用于填补后牙的凹陷和裂缝，但目前的封闭剂要么释放很少的氟化物，要么附着力差。该项目的目标是开发新的释放氟化物的牙齿粘合粘合剂和密封剂。我们假设新的释放氟化物的牙粘接剂和密封剂会将氟化物直接释放到牙齿结构中，改善牙粘接剂，并促进氟化物从释放氟化物的组合物和复合材料或局部氟化物剂转移到牙齿结构中。交流能力。因此，它们可以显著减少龋齿的复发，延长修复体的寿命。以下是year1的进展情况。目的：合成新型黏附螯合单体和f交换螯合物。接受培训成为独立研究人员并获得R01资助。方法：与指导团队合作，参加COBRE培训计划，建立新的实验室，招聘和培训研究人员。结果：成功合成了四种新型黏合剂螯合单体。这些单体可以形成稳定的三元金属氟（f交换）螯合物，可溶于混合水。有机溶剂。其中三种单体由于其高酸度可用于自蚀刻底漆（粘合剂），其中一种单体由于其高氟化物交换能力可用于粘合剂和密封剂。讨论：这些初步结果为明年的工作奠定了重要的基础。展望R01的应用前景。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Introduction: Recurrent caries is the most frequent cause for the failure of dental restorations. Fluoride-releasing restorative materials can reduce recurrent caries at the restoration margins. However, current dental composites and compomers have low fluoride release and recharge capabilities and they require bonding agents to bond to the tooth structure. Current dental bonding agents also have little fluoride-releasing and recharging capabilities and form a barrier hindering the transport of fluoride. Sealants have been used to fill the pits and fissures in posterior teeth but current sealants either release little fluoride or have poor adhesion. The goal of this project is to develop new fluoride-releasing dental bonding adhesives and sealants. We hypothesize that new fluoride-releasing dental bonding adhesives and sealants will release fluoride directly into the tooth structure, improve bonding, and facilitate the transport of fluoride from fluoride-releasing compomers and composites or topic fluoride agents to the tooth structure due to the fluoride?exchange capability. Therefore, they can significantly reduce the recurrent caries and prolong the life of the restoration. The following is the progress in year1. Objective: To synthesize new adhesive chelating monomers and F-exchange chelates. To be trained to become independent researcher and to obtain a R01 grant. Methods: Worked with the mentoring team, attended the COBRE training program, set up a new laboratory, hired and trained research associates. Results: Four new adhesive chelating monomers have been successfully synthesized. These monomers can form stable ternary metal fluoride (F-exchange) chelates that are soluble in mixed water?organic solvents. Three of the monomers may be used in self-etching primer (bonding agents) due to their high acidity, and one of them may be used in adhesives and sealants due to its high fluoride-exchange capability. Discussion: These preliminary results have laid an important foundation for the next year?s study and the future R01 application.