Nutritional and Heavy Metals: Effects on Child Learning and Behavior in Uruguay

营养和重金属：对乌拉圭儿童学习和行为的影响

• 批准号: 7688657
• 负责人: Katarzyna Kordas
• 金额: $ 12.49万
• 依托单位: PENNSYLVANIA STATE UNIVERSITY, THE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-17 至 2012-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7688657
• 关键词: 7 year old; Address; Affect; Age; Anemia; Area; Arsenic; Behavior; Behavior Disorders; Behavioral; Biometry; Child; Childhood; Clinic; Cognition; Cognitive; Collaborations; Collection; Communities; Complex; Country; Data; Developed Countries; Developing Countries; Development; Developmental Disabilities; Diagnosis; Economics; Environmental Epidemiology; Environmental Exposure; Environmental Pollution; Epidemiologic Studies; Epidemiology; Future; Goals; Growth; Heavy Metals; Hospitals; Human Resources; Income; Infant; Institution; Investigation; Iron; Lead; Learning; Learning Disabilities; Malnutrition; Manganese; Mercury; Metal exposure; Nature; Needs Assessment; Neurocognitive; Neurodevelopmental Disability; Nutritional; Nutritionist; Performance; Prevalence; Process; Psychologist; Public Health; Public Health Schools; Research; Research Design; Research Infrastructure; Resources; Risk Factors; School-Age Population; Schools; Screening procedure; Severities; Time; Toxic Environmental Substances; Toxic effect; Toxicant exposure; Toxin; Trace metal; Training; Universities; Uruguay; Woman; aged; base; design; epidemiology study; forging; lead exposure; modifiable risk; pediatrician; prevent; psychosocial; public health relevance; social; stressor; toxicant

DESCRIPTION (provided by applicant): Neurodevelopmental disabilities in children from low-to-middle income countries produce a substantial negative impact on societal and economic growth. Many of the causes of developmental disabilities, such as environmental toxins, nutritional deficiencies, psychosocial stressors, are common in resource-poor countries. Young children are particularly vulnerable to environmental exposures because rapid development creates windows of opportunity for toxins to exert their effects. In areas of the world where little research on neurodevelopmental disabilities has been conducted, it is necessary to assess the prevalence and nature of cognitive and behavioral deficits. In Montevideo, Uruguay, there is evidence that children are exposed to multiple heavy metals. However, to date very little research exists in this unique setting to understand the effects of multiple metal exposures on cognition, behavior, and school performance of urban children. There is also no research on how these exposures could be prevented or mitigated. We propose to conduct an investigation of cognitive performance and behavior in 200 children aged 6-7 years from Montevideo, Uruguay. Early school age is a period of important intellectual and social growth, and it sets up children's scholastic trajectories. At this time, learning disabilities often become manifested and diagnosed in children. It is also an age when environmental insults are clearly manifested. The goal of this project is to build research capacity and infrastructure in environmental epidemiology. Also, it is to investigate the relationship between heavy metal exposures (lead, arsenic, mercury), trace metals (iron and manganese) and cognition, behavior, and school performance in children from Montevideo, Uruguay. In the process of collecting data, we will identify key steps in the research process that will require additional training or resources. PUBLIC HEALTH RELEVANCE: Neurodevelopmental disabilities in children from low-to-middle income countries produce a substantial negative impact on societal and economic growth. Many of the causes of developmental disabilities, such as environmental toxins and nutritional deficiencies are common in resource-poor countries. We will conduct an investigation of cognitive performance and behavior in 200 children aged 6-7 years from Montevideo, Uruguay to understand the complex relationship between heavy metal exposures (lead, arsenic, mercury), trace metals (iron and manganese), and cognition, behavior, and school performance in children.

说明(申请人提供)：中低收入国家儿童的神经发育障碍对社会和经济增长产生重大负面影响。造成发育障碍的许多原因，如环境毒素、营养不足、心理社会压力等，在资源贫乏的国家很常见。幼儿特别容易受到环境暴露的影响，因为快速发展为毒素发挥作用创造了机会之窗。在世界上对神经发育障碍研究很少的地区，有必要评估认知和行为缺陷的患病率和性质。在乌拉圭蒙得维的亚，有证据表明儿童暴露在多种重金属中。然而，到目前为止，在这种独特的环境下，很少有研究了解多重金属暴露对城市儿童的认知、行为和学习表现的影响。也没有关于如何预防或减轻这些暴露的研究。我们建议对乌拉圭蒙得维的亚200名6-7岁儿童的认知表现和行为进行调查。学龄前期是智力和社会发展的重要时期，它决定了孩子们的学业轨迹。在这个时候，学习障碍往往会在儿童身上表现出来并被诊断出来。这也是一个环境侮辱明显表现出来的时代。该项目的目标是建设环境流行病学的研究能力和基础设施。此外，它还将调查乌拉圭蒙得维的亚儿童接触重金属(铅、砷、汞)和痕量金属(铁和锰)与认知、行为和学习表现之间的关系。在收集数据的过程中，我们将确定研究过程中需要额外培训或资源的关键步骤。公共卫生相关性：中低收入国家儿童的神经发育障碍对社会和经济增长产生重大负面影响。造成发育障碍的许多原因，例如环境毒素和营养不足，在资源贫乏的国家很常见。我们将对乌拉圭蒙得维的亚200名6-7岁儿童的认知表现和行为进行调查，以了解重金属暴露(铅、砷、汞)、痕量金属(铁和锰)与儿童认知、行为和学习表现之间的复杂关系。

项目成果

Nutritional status and diet as predictors of children's lead concentrations in blood and urine.

• DOI: 10.1016/j.envint.2017.11.013
• 发表时间: 2018-03
• 期刊: Environment international
• 影响因子: 11.8
• 作者: Kordas K;Burganowski R;Roy A;Peregalli F;Baccino V;Barcia E;Mangieri S;Ocampo V;Mañay N;Martínez G;Vahter M;Queirolo EI
• 通讯作者: Queirolo EI

Multiple-metal exposure, diet, and oxidative stress in Uruguayan school children.

乌拉圭学童的多种金属暴露、饮食和氧化应激。

• DOI: 10.1016/j.envres.2018.06.028
• 发表时间: 2018
• 期刊: Environmental research
• 影响因子: 8.3
• 作者: Kordas,Katarzyna;Roy,Aditi;Vahter,Marie;Ravenscroft,Julia;Mañay,Nelly;Peregalli,Fabiana;Martínez,Gabriela;Queirolo,ElenaI
• 通讯作者: Queirolo,ElenaI

Do Neighborhood Factors Modify the Effects of Lead Exposure on Child Behavior?

邻里因素是否会改变铅暴露对儿童行为的影响？

• DOI: 10.3390/toxics10090517
• 发表时间: 2022-08-31
• 期刊: Toxics
• 影响因子: 4.6
• 作者: Frndak S;Barg G;Queirolo EI;Mañay N;Colder C;Yu G;Ahmed Z;Kordas K
• 通讯作者: Kordas K

A cross-sectional study of general cognitive abilities among Uruguayan school children with low-level arsenic exposure, potential effect modification by methylation capacity and dietary folate.

• DOI: 10.1016/j.envres.2018.02.021
• 发表时间: 2018-07
• 期刊: Environmental research
• 影响因子: 8.3
• 作者: Desai G;Barg G;Queirolo EI;Vahter M;Peregalli F;Mañay N;Kordas K
• 通讯作者: Kordas K

Contribution of household drinking water intake to arsenic and lead exposure among Uruguayan schoolchildren.

家庭饮用水摄入量对乌拉圭学童砷和铅暴露的影响。

• DOI: 10.1016/j.chemosphere.2022.133525
• 发表时间: 2022
• 期刊: Chemosphere
• 影响因子: 8.8
• 作者: Rowan,Jennifer;Kordas,Katarzyna;Queirolo,ElenaI;Vahter,Marie;Mañay,Nelly;Peregalli,Fabiana;Desai,Gauri
• 通讯作者: Desai,Gauri