SIGNAL TRANSDUCTION COMPLEXES

信号转导复合体

• 批准号: 7598629
• 负责人: THEODORE G WENSEL
• 金额: $ 1.63万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7598629
• 关键词: Complex; Computer Retrieval of Information on Scientific Projects Database; Cyclic GMP; Enzymes; Funding; Grant; Heterotrimeric G Protein Subunit; Ice; Institution; Lipid Bilayers; Lipids; Membrane Proteins; Peripheral; Phototransduction; Proteins; Research; Research Personnel; Resources; Signal Transduction; Solutions; Source; Transducin; United States National Institutes of Health; phosphoric diester hydrolase

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project involves two proteins, the alpha subunit of the heterotrimeric G protein of phototransduction, transducin (Gat), and its effector enzyme, cGMP phosphodiesterase (PDE6), a heterotetrameric protein with two catalytic (ab) and two inhibitory subunits (rr). Both PDE6 and Gat are peripheral membrane proteins with covalently attached lipids and we have studied their complexes both in solution (ice) and attached to lipid bilayer membranes.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 该项目涉及两种蛋白质，光转导的异源三聚体G蛋白的α亚基，转导素（Gat），及其效应酶，cGMP磷酸二酯酶（PDE 6），具有两个催化亚基（ab）和两个抑制亚基（rr）的异源四聚体蛋白。 PDE 6和Gat都是具有共价连接的脂质的外周膜蛋白，并且我们已经研究了它们在溶液（冰）中和连接到脂质双层膜的复合物。