NONINVASIVE MEASUREMENT OF BLOOD ANALYTES

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 该项目的目标是使用近红外拉曼光谱法测量人类受试者血液组织基质中的临床相关分析物，短期研究针对糖尿病患者的葡萄糖测量。 这项技术可能会极大地影响整个人口的医疗保健实践。 在最近的研究中，我们证明了从前臂的经皮测量中检测体内葡萄糖浓度的可行性。 下一个障碍是证明校准转移，即将算法应用于校准程序期间未使用的数据并成功预测葡萄糖浓度。我们目前的努力是通过一个精心设计的程序，采用体外研究和体内狗和人的研究，朝着这个目标。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this project is the measurement of clinically-relevant analytes in the blood tissue matrix of human subjects using near-infrared Raman spectroscopy, with the shorter term research directed towards glucose measurements for diabetic patients. This technology could greatly impact the healthcare practices for the entire population. In recent research we demonstrated detection feasibility of glucose concentrations in vivo from transcutaneous measurements of the forearm. The next hurdle is to demonstrate calibration transfer, i.e. apply the algorithm to data not utilized during the calibration procedure and successfully predict glucose concentrations. Our current efforts are directed towards this aim by means of a carefully designed program employing in vitro studies and in vivo dog and human studies.