NONINVASIVE MEASUREMENT OF BLOOD ANALYTES

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 该项目的目标是使用近红外拉曼光谱测量受试者血液组织基质中与临床相关的分析物，短期研究针对糖尿病患者的血糖测量。这项技术可能会极大地影响整个人口的医疗实践。在最近的研究中，我们证明了通过对前臂进行经皮测量来检测体内葡萄糖浓度的可行性。下一个障碍是演示校准转移，即将算法应用于校准过程中未使用的数据，并成功预测葡萄糖浓度。我们目前的努力是通过精心设计的计划来实现这一目标，该计划采用了体外研究和在体狗和人体研究。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this project is the measurement of clinically-relevant analytes in the blood tissue matrix of human subjects using near-infrared Raman spectroscopy, with the shorter term research directed towards glucose measurements for diabetic patients. This technology could greatly impact the healthcare practices for the entire population. In recent research we demonstrated detection feasibility of glucose concentrations in vivo from transcutaneous measurements of the forearm. The next hurdle is to demonstrate calibration transfer, i.e. apply the algorithm to data not utilized during the calibration procedure and successfully predict glucose concentrations. Our current efforts are directed towards this aim by means of a carefully designed program employing in vitro studies and in vivo dog and human studies.