NONINVASIVE MEASUREMENT OF BLOOD ANALYTES

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。该项目的目标是使用近红外拉曼光谱测量人体受试者血液组织基质中的临床相关分析物。这种技术可能会对整个人群的医疗保健实践产生巨大影响，短期研究将针对糖尿病患者的血糖测量。我们最近证明了通过前臂经皮测量体内葡萄糖浓度检测的可行性。从这些测量中，我们发现一个重要的误差来源是样品浊度的可变性。因此，我们正在探索通过在同一收集点同时获取漫反射光谱来校正混浊引起的拉曼光谱畸变。我们相信恢复的本征拉曼光谱可以提供更好的分析物测量精度。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this project is the measurement of clinically-relevant analytes in the blood tissue matrix on human subjects using near-infrared Raman spectroscopy. Such a technology could have great impact on the healthcare practices for the entire population, with the shorter term research directed towards glucose measurements for diabetic patients. We have recently demonstrated detection feasibility of glucose concentrations in vivo from transcutaneous measurements of the forearm. From these measurements we discovered that one important source of error is variability in sample turbidity. As a result, we are exploring a correction for the turbidity-induced distortions on Raman spectra via simultaneously acquiring diffuse reflectance spectra at the same collection site. We believe that the recovered intrinsic Raman spectra could offer better analyte measurement accuracy.