MIT LASER BIOMEDICAL RESEARCH CENTER

描述(由申请人提供)：麻省理工学院激光生物医学研究中心(LBRC)成立于1985年，通过NIH的持续资助，该中心继续巩固和扩大规模。根据拟议的计划，研究和开发将通过核心、合作和外部项目进行，培训和教育将在本科生、研究生和研究生层面进行，而信息传播将通过我们实验室的出版物-光谱仪-和其他各种交流来保持。融合了光学光谱、成像、散射和干涉测量的实验技术将应用于从亚细胞尺度到整个器官尺度的健康和疾病生物结构的生物物理和生化研究。基于近红外拉曼散射、本征荧光、漫反射和单光散射的基于探测器的光谱诊断仪器将提供关于人类疾病的补充数据，并将探索将这些技术结合到单一、多功能仪器中的可能性。这项多模式检查将应用于各种器官的诊断，包括宫颈、口腔、巴雷特食道、动脉、乳房、皮肤，以及经皮血液成分的测量。光谱成像将朝着广域组织定征和层析成像的方向发展。弹性光散射研究将有助于我们理解亚微米尺度的组织结构。定量干涉显微镜的新技术将被用于在纳米水平上测量细胞结构。与神经元动作电位和膜波动相关的快速细胞运动将在亚毫秒尺度上量化。未来LBRC的研究工作将集中在现有领域，以及新的和极其令人兴奋的核心项目上。还将建立其他几个前景看好的合作项目。将提供现代化的设施，新的核心研究人员和外部合作者将加入该中心。

DESCRIPTION (provided by applicant): Established in 1985, the MIT Laser Biomedical Research Center (LBRC) has continued to consolidate and expand through sustained NIH funding. Under the proposed program, the research and development will progress through core, collaborative and outside projects, the training and education will be carried out at the undergraduate, graduate and postgraduate level, while the information dissemination will be maintained through our laboratory's publication -The Spectrograph- and various other communications. Experimental techniques that merge optical spectroscopy, imaging, scattering, and interferometry will be applied to study the biophysics and biochemistry of healthy and diseased biological structures from the subcellular to the entire-organ scale. Probe-based spectral diagnosis instruments based on near-infrared Raman scattering, intrinsic fluorescence, diffuse reflectance, and single light scattering will provide complementary data on human disease and the possibility of combining these techniques into a single, versatile instrument will be explored. This multimodal investigation will be applied for diagnostics in various organs, including cervix, oral cavity, Barrett's esophagus, artery, breast, skin, as well as for transcutaneous measurements of blood constituents. Spectroscopic imaging will advance in the direction of wide-area tissue characterization and tomography. Elastic light scattering studies will contribute to our understanding of tissue organization at the sub-micron scale. New technology on quantitative interferometric microscopy will be exploited for measuring cellular structures at the nanometer level. Rapid cell motions associated with neuronal action potentials and membrane fluctuations will be quantified at the sub-millisecond scale. The future LBRC research effort will channel on existing areas, as well as on new and extremely exciting core projects. Several additional, promising collaborative projects will be established. Modern facilities will be made available and new core research staff and outside collaborators will join the center.