PHYSICAL INFRASTRUCT FOR CELL BIOLOGICAL MODELS DEVELOPMENT OF PCG ALGORITHM

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Virtual Cell default linear solver uses the preconditioned conjugate gradient method (PCG) that has been extended to include a more general minimal residual algorithm (GMRES), which is applicable to non-symmetrical matrices.. Recently, new algorithms for discretization of reaction-diffusion-advection equations (central difference, upwind, and hybrid) have been implemented. The new capability to model advection along with diffusion and reactions can be applied to study competition of various molecular motors driving organelles along cytoskeletal filaments. Improvements to the solver are an ongoing project.