RATE OF IN VIVO ACTIN POLYMERIZATION BASED ON FRAP MEASUREMENTS

基于 FRAP 测量的体内肌动蛋白聚合率

• 批准号: 8362511
• 负责人: BORIS SLEPCHENKO
• 金额: $ 1.05万
• 依托单位: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362511
• 关键词: Actins; Biological Models; Cells; Data Analyses; Development; Funding; Grant; Measurement; Modeling; National Center for Research Resources; Principal Investigator; Research; Research Infrastructure; Resources; Source; Study models; Time; United States National Institutes of Health; base; cost; in vivo; polymerization; virtual

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The study involves determination of a rate of in vivo actin polymerization in steady-state conditions, based on FRAP measurements. This collaborative study collaborative studies involves development of cell-biological models that have potential for generalization and implementation in the Virtual Cell. Such studies, where models are necessary for data analysis and/or better qualitative understanding of cell phenomena, serve as motivators (and at the same time as testbeds) for further development of the Virtual Cell.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其他NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 该研究涉及确定在稳态条件下，基于FRAP测量的体内肌动蛋白聚合的速率。这种协作研究涉及开发具有在虚拟细胞中推广和实施潜力的细胞生物学模型。 此类研究中，模型对于数据分析和/或更好地定性理解细胞现象是必要的，可以作为虚拟细胞进一步开发的激励因素（同时也是测试平台）。