BIOPHYSICAL MECHANISMS FOR MODELS OF CYTOSKELETAL DYNAMICS

细胞骨架动力学模型的生物物理机制

• 批准号: 8169570
• 负责人: BORIS SLEPCHENKO
• 金额: $ 8.16万
• 依托单位: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8169570
• 关键词: Biochemical; Cereals; Computer Retrieval of Information on Scientific Projects Database; Cytoskeletal Modeling; Event; Filament; Funding; Grant; Institution; Kinetics; Mechanics; Movement; Probability; Research; Research Personnel; Resources; Source; Time; United States National Institutes of Health; depolymerization; monomer; polymerization; simulation

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project focuses on prototyping various computational approaches, both detailed stochastic and coarse-grain continuous, to modeling cytoskeletal dynamics. A detailed stochastic approach entails kinetic Monte Carlo simulations of both biochemical events, such as nucleation of filaments and polymerization and depolymerization events, and mechanical effects, such as movements of monomers and filaments in the presence of mechanical forces and stochastic fluctuations. A continuous approximation will be formulated in terms of ensemble averages or, in more detail, in terms of probability distributions in space and time.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 这个项目的重点是原型的各种计算方法，包括详细的随机和粗粒度连续，建模细胞骨架动力学。一个详细的随机方法需要动力学蒙特卡罗模拟的生化事件，如成核的细丝和聚合和解聚事件，和机械效应，如运动的单体和细丝中存在的机械力和随机波动。一个连续的近似将制定在整体平均，或更详细地说，在空间和时间的概率分布方面。