GENETICS OF ATOPIC DERMATITIS: ECZEMA HERPETICUM STUDY

特应性皮炎的遗传学：疱疹性湿疹研究

• 批准号: 7604356
• 负责人: DONALD YM LEUNG
• 金额: $ 1.78万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604356
• 关键词: Atopic Dermatitis; Computer Retrieval of Information on Scientific Projects Database; Condition; Disease Outbreaks; Eczema Herpeticum; Eczema Vaccinatum; Funding; Genes; Genetic; Grant; Herpes Simplex Infections; Infectious Skin Diseases; Institution; Learning; Life; Patients; Reaction; Research; Research Personnel; Resources; Risk; Simplexvirus; Skin; Smallpox Vaccine; Source; United States National Institutes of Health; Viral

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study is being done to learn more about why atopic dermatitis patients get more viral skin infections such as Herpes simplex. When atopic dermatitis patients get disseminated skin outbreaks with herpes simplex virus, that condition is called eczema herpeticum (EH). Investigators are looking for the genes that increase the risk of having this condition. Changes in a gene can mean that some people may be more likely to have eczema herpeticum than others. The genes of patients who have eczema herpeticum will be compared to the genes of people who do not have this condition. Investigators have chosen to focus upon EH because it is felt to represent a reasonable, "real-life" surrogate for eczema vaccinatum (EV). EV is a severe and life threatening reaction to the smallpox vaccine.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 这项研究是为了了解更多关于为什么特应性皮炎患者得到更多的病毒性皮肤感染，如单纯疱疹。当特应性皮炎患者获得传播性皮肤单纯疱疹病毒爆发，这种情况被称为疱疹性湿疹（EH）。 研究人员正在寻找增加患这种疾病风险的基因。基因的变化可能意味着有些人可能比其他人更容易患疱疹性湿疹。 患有疱疹性湿疹的患者的基因将与没有这种情况的人的基因进行比较。 研究者选择关注EH，因为它被认为是疫苗性湿疹（EV）的合理的“现实生活”替代品。 EV是对天花疫苗的严重和危及生命的反应。