GENETICS OF ATOPIC DERMATITIS: ECZEMA HERPETICUM STUDY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究是为了更多地了解为什么特应性皮炎患者会患上更多的病毒性皮肤感染，如单纯疱疹病毒。当特应性皮炎患者出现单纯疱疹病毒播散性皮肤爆发时，这种情况称为疱疹湿疹(EH)。研究人员正在寻找增加患这种疾病风险的基因。基因的变化可能意味着一些人可能比其他人更有可能患有疱疹湿疹。疱疹湿疹患者的基因将与没有这种情况的人的基因进行比较。研究人员选择将重点放在EH上，因为人们认为EH代表了湿疹疫苗(EV)的一个合理的、“现实生活”的替代品。EV是对天花疫苗的严重和危及生命的反应。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study is being done to learn more about why atopic dermatitis patients get more viral skin infections such as Herpes simplex. When atopic dermatitis patients get disseminated skin outbreaks with herpes simplex virus, that condition is called eczema herpeticum (EH). Investigators are looking for the genes that increase the risk of having this condition. Changes in a gene can mean that some people may be more likely to have eczema herpeticum than others. The genes of patients who have eczema herpeticum will be compared to the genes of people who do not have this condition. Investigators have chosen to focus upon EH because it is felt to represent a reasonable, "real-life" surrogate for eczema vaccinatum (EV). EV is a severe and life threatening reaction to the smallpox vaccine.