Translating Mussel Adhesion
翻译贻贝粘附力
基本信息
- 批准号:7668044
- 负责人:
- 金额:$ 42.78万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2008
- 资助国家:美国
- 起止时间:2008-08-04 至 2013-06-30
- 项目状态:已结题
- 来源:
- 关键词:AdhesionsAdhesivesBehaviorChemicalsCollagenDentalDentistryDopaDrug FormulationsEngineeringExhibitsGlycineGoalsHydroxyapatitesHydroxyprolineIn VitroLinkMarinesMass Spectrum AnalysisMeasuresMetalsMineralsModificationMolecularMono-SMusselsOrthopedicsPhosphoserinePolymersPost-Translational Protein ProcessingPreparationProlinePropertyProteinsRelianceRoleSerineSideSolidSurfaceTechnologyTissuesTitaniumTranslatingWateradhesive polymeradhesive protein (mussel)basecrosslinkimplant materialimprovedin vivomarine organismmolecular masspromoterprotein protein interactionpublic health relevancerepairedrestoration
项目摘要
DESCRIPTION (provided by applicant): Moisture is the nemesis of strong polymer adhesion to metals and minerals. Most engineered adhesive polymers require extensive prior surface cleaning, drying, and sometimes even chemical modification for effective adhesion to polar surfaces. Such surface preparation is difficult in vivo since biomineralized tissues and implant material surfaces are necessarily hydrated within the body. Various marine organisms have evolved highly effective adhesive strategies for wet surfaces. The broad goal of this proposal is to obtain mechanistic information about marine adhesion in order to translate it into effective applications for restoration and repair of hard tissues. While the discovery of 3,4-dihydroxyphenylalanine (Dopa)-protein involvement in adhesion has already inspired several new biomedical materials, Dopa is not the only bioinspired theme. The specific aims here are to determine using mass spectrometry whether and to what extent phosphoserine and 4-hydroxyarginine are linked to mussel adhesion on different surfaces, characterize the specific protein-protein interactions during adhesive cross-linking, and to explore how factors such as mass, primary sequence, and side- chain functionalization influence the coating or bridging behavior of mfp-1 on surfaces such as titanium and hydroxyapatite using the surface forces apparatus. Bio-inspired adhesives and sealants are much needed in dentistry and orthopedics not just to improve the strength and durability of bonding to hard tissues, but also to emancipate the present technology, particularly in dentistry, from a reliance on highly reactive and toxic organic formulations. PUBLIC HEALTH RELEVANCE: In dental and biomedical restorations, water is the nemesis of true adhesion between solid surfaces and polymers. The strong underwater adhesion of marine organisms such as mussels is based on an adaptive set of molecular and biophysical properties that will be systematically translated into medically relevant strategies.
描述(由申请人提供): 水分是聚合物对金属和矿物的强力粘附力的克星。大多数工程粘合剂聚合物需要事先进行大量的表面清洁、干燥,有时甚至需要进行化学改性,才能有效粘附到极性表面。这种表面制备在体内是困难的,因为生物矿化组织和植入材料表面必须在体内水合。各种海洋生物已经进化出了针对潮湿表面的高效粘合策略。该提案的主要目标是获得有关海洋粘附的机械信息,以便将其转化为硬组织恢复和修复的有效应用。虽然 3,4-二羟基苯丙氨酸 (Dopa) 蛋白参与粘附的发现已经启发了几种新的生物医学材料,但多巴并不是唯一的生物启发主题。这里的具体目标是使用质谱法确定磷酸丝氨酸和 4-羟基精氨酸是否以及在多大程度上与不同表面上的贻贝粘附相关,表征粘附交联过程中特定的蛋白质-蛋白质相互作用,并探索质量、一级序列和侧链功能化等因素如何影响 mfp-1 在钛等表面上的涂层或桥接行为。 使用表面力装置测量羟基磷灰石。牙科和骨科领域非常需要仿生粘合剂和密封剂,不仅可以提高与硬组织粘合的强度和耐久性,而且可以使现有技术(特别是牙科领域)摆脱对高反应性和有毒有机配方的依赖。公共健康相关性:在牙科和生物医学修复中,水是固体表面和聚合物之间真正粘附力的克星。贻贝等海洋生物在水下的强大粘附力是基于一组适应性的分子和生物物理特性,这些特性将被系统地转化为医学相关策略。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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JOHN HERBERT WAITE其他文献
JOHN HERBERT WAITE的其他文献
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{{ truncateString('JOHN HERBERT WAITE', 18)}}的其他基金
Biomimetic Blades: Mincing with Less Mineral
仿生刀片:用更少的矿物质进行切碎
- 批准号:
6900216 - 财政年份:2003
- 资助金额:
$ 42.78万 - 项目类别:
Biomimetic Blades: Mincing with Less Mineral
仿生刀片:用更少的矿物质进行切碎
- 批准号:
6775602 - 财政年份:2003
- 资助金额:
$ 42.78万 - 项目类别:
Biomimetic Blades: Mincing with Less Mineral
仿生刀片:用更少的矿物质进行切碎
- 批准号:
6648105 - 财政年份:2003
- 资助金额:
$ 42.78万 - 项目类别:
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