Cell Migration Consortium

迁移是许多现象的关键过程，包括胚胎发育，癌症，炎症， 和伤口修复。了解细胞迁移的机制是一个巨大的挑战，因为它 是由几个在空间和时间上协调的复杂细胞过程组成的。细胞迁移 联盟是一个高度互动的，多学科的努力，重点是带来新的技术和知识 解决阻碍移徙研究取得进展的障碍。它被组织成跨学科的倡议， 虚拟合作实验室，重点是开发使能技术、试剂和模型， 克服这些阻碍进步的障碍。在联盟的下一阶段，重点将从技术转移到 这是一个非常重要的问题，它的发展，以解决该领域的重大问题的使用。该联盟的目标是：确定， 识别、分类和表征迁移蛋白质组，2）制定数学模型来描述 迁移的步骤，并将其整合成一个综合的迁移模型，3）建立试剂 以及测量、激活和检测调节迁移的局部信号的方法，4）确定 驱动迁移的大型多分子机器的结构，以及5）促进 降低进入该领域的门槛。为了实现这些目标， 由各个倡议开发的信息将通过倡议间合作在联盟中共享 在移民社区内外。该联盟分为7个倡议。Proteomics (mass磷酸化和结合配偶体的基于光谱分析）、发现（表达测定 以鉴定几种生物体中的迁移分子）、转基因和敲除小鼠（产生 条件性敲除和RNAi敲除小鼠），结构（确定 迁移复合物），生物传感器（新的生物传感器的开发和应用，以测量空间 信号传导），成像和光操纵（光活化的开发和应用， 光灭活，牵引力测定和相关显微镜），建模（开发数学模型）， 细胞迁移模型），以及数据协调和传播核心（组织信息， 财团和社区。联盟的资源将通过 Cell Migration Gateway，与Nature Publishing Group合作。

Migration is a pivotal process in many phenomena including embryonic development, cancer, inflammation, and wound repair. Understanding the mechanisms of cell migration present a formidable challenge, since it is comprised of several complex cellular processes coordinated in space and time. The Cell Migration Consortium is a highly interactive, multidisciplinary effort focused on bringing novel technical and intellectual solutions to the barriers to progress in migration research. It is organized into interdisciplinary Initiatives, virtual collaborative laboratories, focused on developing enabling technologies, reagents and models to address these barriers to progress. In the Consortium's next phase the emphasis will shift from technology development to its use in addressing major questions in the field. The Consortium goals are: to determine, identify, catalogue, and characterize the migration proteome, 2) formulate mathematical models to describe the steps in migration and integrate them into a comprehensive model of migration, 3) establish reagents and methods to measure, activate, and inactivate local signals that regulate migration, 4) determine the structures of the large multi-molecular machines that drive migration, and 5) promote migration research in the community and lower barriers for entry into the field. To achieve these goals enabling technologies developed by the individual Initiatives will be shared across the Consortium via inter-Initiative collaborations both inside and outside the migration community. The Consortium is organized into 7 Initiatives. Proteomics (mass spectrometry based analyses of phosphorylation and binding partners), Discovery (expression assays to identify migration molecules in several organisms), Transgenic and Knockout Mouse (production of conditional knockout and RNAi knockdown mice), Structure (determination of high resolution structures of migration complexes), Biosensors (development and application of new biosensors to measure spatial signaling), Imaging and Photomanipulation (development and application of photoactivation, photoinactivation, traction force assays, and correlation microscopy), Modeling (develop mathematical models of cell migration), and a Data Coordination and Dissemination Core (organize information for the Consortium and the community. The Consortium resources will be disseminated to the Community via the Cell Migration Gateway, a collaboration with the Nature Publishing Group.