Cell Migration Consortium

迁移是许多现象的关键过程，包括胚胎发育、癌症、炎症、 和伤口修复。理解细胞迁移的机制是一个艰巨的挑战，因为它 是由几个在空间和时间上协调的复杂细胞过程组成的。细胞迁移 联盟是一个高度互动的、多学科的努力，专注于带来新的技术和智力 解决移徙研究取得进展的障碍。它被组织成跨学科的倡议， 虚拟协作实验室，专注于开发使能技术、试剂和模型 解决这些阻碍进步的障碍。在财团的下一阶段，重点将从技术转向 发展将其用于解决实地的主要问题。该联盟的目标是：确定， 识别、分类和表征迁移蛋白质组，2)建立数学模型来描述 迁移的步骤并将它们集成到迁移的综合模型中，3)建立试剂 以及测量、激活和停用调节迁移的局部信号的方法，4)确定 驱动迁移的大型多分子机器的结构，以及5)促进迁移研究 社区和较低的进入该领域的门槛。为了实现这些目标，使技术 由各个计划开发的内容将通过计划间协作在整个联盟中共享 无论是在移民社区内部还是外部。该联盟由7项倡议组成。蛋白质组学 (基于质谱学的磷酸化和结合配对的分析)、Discovery(表达分析 以鉴定几种生物中的迁移分子)、转基因和基因敲除小鼠(产生 条件基因敲除和RNAi基因敲除小鼠)，结构(高分辨结构的测定 迁移复合体)、生物传感器(用于空间测量的新生物传感器的开发和应用 信号)、成像和光操纵(光激活的发展和应用， 光灭活、牵引力分析和相关显微镜)、建模(发展数学 细胞迁移模型)和数据协调和传播核心(为 财团和社区。财团的资源将通过 细胞迁移网关，与自然出版集团合作。

Migration is a pivotal process in many phenomena including embryonic development, cancer, inflammation, and wound repair. Understanding the mechanisms of cell migration present a formidable challenge, since it is comprised of several complex cellular processes coordinated in space and time. The Cell Migration Consortium is a highly interactive, multidisciplinary effort focused on bringing novel technical and intellectual solutions to the barriers to progress in migration research. It is organized into interdisciplinary Initiatives, virtual collaborative laboratories, focused on developing enabling technologies, reagents and models to address these barriers to progress. In the Consortium's next phase the emphasis will shift from technology development to its use in addressing major questions in the field. The Consortium goals are: to determine, identify, catalogue, and characterize the migration proteome, 2) formulate mathematical models to describe the steps in migration and integrate them into a comprehensive model of migration, 3) establish reagents and methods to measure, activate, and inactivate local signals that regulate migration, 4) determine the structures of the large multi-molecular machines that drive migration, and 5) promote migration research in the community and lower barriers for entry into the field. To achieve these goals enabling technologies developed by the individual Initiatives will be shared across the Consortium via inter-Initiative collaborations both inside and outside the migration community. The Consortium is organized into 7 Initiatives. Proteomics (mass spectrometry based analyses of phosphorylation and binding partners), Discovery (expression assays to identify migration molecules in several organisms), Transgenic and Knockout Mouse (production of conditional knockout and RNAi knockdown mice), Structure (determination of high resolution structures of migration complexes), Biosensors (development and application of new biosensors to measure spatial signaling), Imaging and Photomanipulation (development and application of photoactivation, photoinactivation, traction force assays, and correlation microscopy), Modeling (develop mathematical models of cell migration), and a Data Coordination and Dissemination Core (organize information for the Consortium and the community. The Consortium resources will be disseminated to the Community via the Cell Migration Gateway, a collaboration with the Nature Publishing Group.