Training Program in Organogenesis

描述(由申请人提供)：辛辛那提儿童医院研究基金会(CCHRF)正在提交器官发生培训计划。该计划将提供器官形态发生、畸形发生和修复方面的培训，是CCHRF许多不同部门的主要研究重点。该计划旨在通过将临床和基础科学教师以及对这一研究学科有主要兴趣的受训者聚集在一起，来统一器官发生学的培训。来自九个部门的35名教师将构成该项目导师的核心。这些人包括对器官发生学有主要兴趣的临床医生和基础科学家。CCHRF的教员在儿科(大多数)、外科、放射科和麻醉科担任初级职务。在2004年和2005年的头几个月，这组培训教师拥有180多份出版物，包括《自然》、《细胞》、《科学》、《自然免疫学》、《自然细胞生物学》、《自然医学》、《分子细胞》、《柳叶刀》、《柳叶刀》、《美国国家科学院院刊》和《发育》等主要专业期刊的论文。该项目的实习生将是研究生、博士后研究员和CCHRF的临床研究员。该大学三个专业(医学博士、分子与发育生物学和神经科学)的研究生在CCHRF的实验室进行培训。现有基础科学实验室博士后81人，临床研究员152人。近年来，CCHRF在基础研究方面进行了重大投资，在发育生物学、肺生物学、分子心血管生物学、免疫学和实验血液学等部门招聘了新的教员。该计划将极大地加强和统一CCHRF的主要研究重点之一，并在该领域建立新的领导者，而此时对器官发生的基本机制的洞察可以对儿童先天性器官形成障碍的理解、诊断和治疗产生真正的影响。

DESCRIPTION (provided by applicant): A Training Program in Organogenesis is being submitted by the Cincinnati Children's Hospital Research Foundation (CCHRF). The program will provide training in organ morphogenesis, dysmorphogenesis, and repair, and is a major focus of research in many different divisions at the CCHRF. This program aims to unify training in organogenesis by bringing together both clinical and basic science faculty and trainees with primary interests in this research discipline. Thirty-five faculty from nine divisions will form the core of mentors in the program. These comprise a mix of clinicians and basic scientists with primary interests in organogenesis. Faculty in the CCHRF hold primary appointments in the departments of Pediatrics (the majority), Surgery, Radiology, and Anesthesiology. In 2004 and the first few months of 2005, this group of training faculty has more than 180 publications, including papers in Nature, Cell, Science, Nature Immunology, Nature Cell Biology, Nature Medicine, Molecular Cell, The Lancet, PNAS, and Development, as well as other premier specialist journals. Trainees in this program will be graduate students, postdoctoral fellows, and clinical fellows in training at CCHRF. Graduate students from three programs in the University (M.D./Ph.D., Molecular and Developmental Biology, and Neurosciences) carry out their training in laboratories in the CCHRF. There are currently 81 postdoctoral fellows in basic science laboratories, and 152 clinical fellows. CCHRF has made a major investment in basic research in recent years, by recruiting new faculty in divisions of Developmental Biology, Pulmonary Biology, Molecular Cardiovascular Biology, Immunology, and Experimental Hematology. The program will dramatically enhance and unify one of the major foci of research at CCHRF, and establish new leaders in this field, at a time when insights into the basic mechanisms of organogenesis can make a real impact on the understanding, diagnosis, and treatment of congenital disorders of organ formation in children.