RARC- RESEARCH ANIMAL RESOURCE CENTER

RARC-研究动物资源中心

• 批准号: 7671805
• 负责人: NEIL SCOTT LIPMAN
• 金额: $ 143.53万
• 依托单位: SLOAN-KETTERING INST CAN RESEARCH
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-31 至 2012-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7671805
• 关键词: Accreditation; Anatomy; Animal Experimentation; Animal Model; Animal Welfare; Animals; Area; Arts; Basic Science; Biological; Caring; Clinical; Comparative Pathology; Daily; Development; Diagnosis; Education; Ensure; Environment; Equipment; Genetically Engineered Mouse; Hand; Health; Health Services; Housing; IACUC; Individual; International; Laboratories; Laboratory Animal Medicine; Laboratory Animals; Laboratory Research; Maintenance; Medical; Medical center; Memorial Sloan-Kettering Cancer Center; Methods; Monitor; Neoplasms; New York; Operative Surgical Procedures; Pathology; Phenotype; Play; Policies; Procedures; Quarantine; Regulation; Research; Research Activity; Research Personnel; Resources; Rodent; Role; Science; Services; Support of Research; Surveys; Training; United States National Institutes of Health; United States Public Health Service; Universities; Vendor; Veterinarians; Writing; animal care; animal resource; cancer therapy; college; foot; in vivo; model development; pathogen; programs; quality assurance

The Research Animal Resource Center (RARC) supports animal model development and use at MSKCC. At MSKCC, animal models are used in basic and applied investigational studies. Animals are employed in diverse areas including the development of new methods for diagnosis and treatment of cancer, and the elucidation of the basic biological mechanisms resulting in neoplasia. RARC is comprised of six sections: 1.) Husbandry and Operations; 2.) Animal Health Service (AHS); 3.) Education and Quality Assurance (EQA); 4.) Laboratory of Comparative Pathology (LCP); 5.) Genetically Engineered Mouse Phenotyping (GEM) Core; and, 6.) Administration and Finance, which provide housing for and humane care to over 90,000 animals daily utilized by 99 research laboratories. RARC's oversight of MSKCC's AAALACaccredited, centrally managed, animal care and use program ensures the efficient use of available space and staff resources and allows for close professional monitoring of the in vivo (animal) research program. RARC operates three specialized state-of-the-art facilities encompassing over 66,000 net square feet of space which provide critical environments and the specialized equipment necessary for the maintenance and use of a variety of animal models. RARC's board-certified professional and paraprofessional staff (83 FTE) serve as a consultative and technical resource for MSKCC investigators on all matters related to animal research, The AHS's veterinary and veterinary technical staff ensure that all animals' receive appropriate clinical care and ensure that MSKCC's rodent colonies remain pathogen free by routinely surveying colony health and quarantining all incoming rodents from atypical vendors. Additionally, AHS staff perform technical procedures for research staff in support of their animal research programs. The LCP and the GEM core provide clinical and anatomic pathology services which ensure the health of the resident colonies but are also used extensively in support of individual laboratory's research programs. RARC's extensive educational program is administered by the EQA section which provides training to research staff via didactic and hands-on sessions as well as various written instructional materials. RARC also provides post-graduate training to veterinarians in both Laboratory Animal Medicine and Science, and Comparative Pathology in conjunction with the Weil Medical College of Cornell University, the Rockefeller University, and the Animal Medical Center.

研究动物资源中心（RARC）支持MSKCC的动物模型开发和使用。 在MSKCC，动物模型用于基础和应用研究。动物被用于 不同的领域，包括诊断和治疗癌症的新方法的开发，以及 阐明导致瘤形成的基本生物学机制。RARC由六个部分组成： 1.）的人。饲养和操作; 2.）动物卫生服务（AHS）; 3.）教育和质量保证 (EQA)（4）比较病理学实验室（LCP）; 5.）基因工程小鼠表型分析 (GEM)核心;以及，6.）行政和财政，为超过1000万人提供住房和人道主义照顾。 99个研究实验室每天使用90，000只动物。RARC对MSKCC的AAALA认证的监督， 集中管理的动物护理和使用计划确保有效利用可用空间 和工作人员资源，并允许密切的专业监测体内（动物）研究计划。 RARC运营着三个专业的最先进的设施，占地面积超过66，000平方英尺， 提供关键环境和维护所需的专用设备的空间 以及使用多种动物模型。RARC委员会认证的专业和准专业人员（83 FTE）作为MSKCC调查人员的咨询和技术资源，处理与以下事项有关的所有事项： 动物研究，AHS的兽医和兽医技术人员确保所有动物的接收 适当的临床护理，并确保MSKCC的啮齿动物群落保持无病原体， 调查鼠群的健康状况，并阻止所有来自非典型供应商的啮齿动物进入。此外，AHS工作人员 为研究人员执行技术程序，以支持他们的动物研究计划。lcp和 GEM核心提供临床和解剖病理学服务，确保居民的健康 菌落，但也广泛用于支持个别实验室的研究计划。RARC的 广泛的教育计划由EQA部门管理，为研究人员提供培训 通过教学和实践课程以及各种书面教学材料。 RARC还为兽医提供实验动物医学和 科学和比较病理学与康奈尔大学韦尔医学院， 洛克菲勒大学和动物医疗中心。