Center of Com Med and Pathology

通讯医学与病理学中心

• 批准号: 8933484
• 负责人: NEIL SCOTT LIPMAN
• 金额: $ 245.05万
• 依托单位: SLOAN-KETTERING INST CAN RESEARCH
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8933484
• 关键词: Anatomy; Animal Experimentation; Animal Model; Animals; Area; Basic Science; Biological; Cancer Center Support Grant; Caring; Clinical; Clinical Research; Comparative Pathology; Development; Diagnosis; Education; Ensure; Environment; Equipment; Genetic Engineering; Health; Housing; Individual; Instruction; Laboratories; Laboratory Research; Maintenance; Medicine; Memorial Sloan-Kettering Cancer Center; Methods; Monitor; Neoplasms; Online Systems; Pathology; Phenotype; Procedures; Quarantine; Research; Research Activity; Research Personnel; Resources; Rodent; Services; Surveys; Training; Translational Research; Vendor; Work; Writing; animal care; animal model development; animal resource; biosecurity; cancer therapy; clinical care; comparative; operation; pathogen; programs; quality assurance; square foot

The Center of Comparative Medicine and Pathology (CCMP) supports animal model development and use through its Research Animal Resource Center (RARC) and Laboratory of Comparative Pathology (LCP). At MSKCC, animal models are used in basic and applied investigational studies as well as for training of both clinical and research staff. Animals are employed in diverse areas including the development of new methods for diagnosis and treatment of cancer as well as the elucidation of the basic biological mechanisms resulting in neoplasia. CCMP's professional and paraprofesslonal staff (131 FTE) serve as a consultative and technical resource for MSKCC investigators on all matters related to animal research. RARC is comprised of four sections: 1) Biosecurity; 2) Education and Quality Assurance (EQA); 3) Husbandry and Operations (H&O); and 4) Veterinary Services (VS). RARC provides housing for and humane care to over 170,000 animals daily, utilized by 140 investigators. PARC's oversight of MSKCC's AAALAC-accredited, centrally managed, animal care program ensures the efficient use of available space and staff resources and allows for close professional monitoring of the animal research program. Biosecurity ensures that MSKCC's rodent colonies remain pathogen free by routinely surveying colony health and quarantining incoming rodents from vendors. EQA administers an extensive educational program which provides training to animal care and research staff via didactic and hands-on sessions, web based tutorials as well as written instructional materials. PARC's H&O section operates three specialized state-of-the-art facilities encompassing over 80,700 net square feet of space which provide critical environments and the specialized equipment necessary for the maintenance and use of a variety of animal models. VS's staff ensure that all animals' receive appropriate clinical care and perform technical procedures for research staff. The LCP, a multi-disciplinary pathology laboratory and its Genetically Engineered Animal (GEA) Phenotyping Service supports individual laboratory's research and PARC's programs by providing clinical and anatomic pathology services and extensive phenotypic profiles of GEA.

比较医学和病理学中心（CCMP）支持动物模型的开发， 通过其研究动物资源中心（RARC）和比较病理学实验室使用 （LCP）。在MSKCC，动物模型用于基础和应用研究，以及 培训临床和研究人员。动物被用于不同的领域，包括开发 癌症诊断和治疗的新方法以及基本生物学原理的阐明 导致肿瘤形成的机制。CCMP的专业和准专业人员（131 FTE）担任 为MSKCC研究者提供与动物研究相关的咨询和技术资源。 RARC由四个部分组成：1）生物安全; 2）教育和质量保证; 3） 畜牧和运营（H&O）;和4）兽医服务（VS）。RARC提供住房， 每天为超过170，000只动物提供人道护理，由140名研究人员使用。PARC对MSKCC的监督 AAALAC认证的集中管理的动物护理计划确保有效利用可用空间 和工作人员资源，并允许密切的专业监测动物研究计划。生物安保 确保MSKCC的啮齿动物群落保持病原体通过定期调查殖民地的健康和 从商贩那里拦截啮齿动物。EQA管理着一个广泛的教育计划， 通过教学和实践课程，基于网络的教程，为动物护理和研究人员提供培训 以及书面教学材料。帕洛阿尔托研究中心的H&O部门运作着三个专业的最先进的 设施占地超过80，700平方英尺，提供关键的环境和 维护和使用各种动物模型所需的专用设备。VS工作人员 确保所有动物都得到适当的临床护理，并为研究人员执行技术程序。 LCP，一个多学科病理学实验室及其基因工程动物（GEA）表型 服务支持个别实验室的研究和PARC的计划，提供临床和解剖 病理学服务和广泛的GEA表型特征。