Center of Com Med and Pathology

比较医学和病理学中心(CCMP)支持动物模型的开发和 通过其研究动物资源中心(RARC)和比较病理学实验室使用 (LCP)。在MSKCC，动物模型用于基础和应用研究以及 临床和研究人员的培训。动物被用于不同的领域，包括开发 癌症诊断和治疗的新方法以及基本生物学的阐明 导致肿瘤形成的机制。CCMP的专业和准专业工作人员(131 FTE)担任 为MSKCC调查人员提供与动物研究相关的咨询和技术资源。 RARC由四个部分组成：1)生物安全；2)教育和质量保证；3) 畜牧及营运(H&O)；及4)兽医服务(VS)。RARC为和提供住房 每天向超过17万只动物提供人道关怀，由140名调查人员使用。帕洛阿尔托研究中心对MSKCC AAALAC认证的集中管理的动物护理计划确保有效利用可用空间 以及人力资源，并允许对动物研究计划进行密切的专业监督。生物安全 确保MSKCC的啮齿动物群体保持无病原体，通过定期调查群体健康和 隔离来自供应商的进来的啮齿动物。EQA管理着一个广泛的教育项目， 通过授课和实践课程、基于网络的教程为动物护理和研究人员提供培训 以及书面教学材料。帕洛阿尔托研究中心的H&O部门经营着三个专业的最先进的 设施面积超过80,700平方英尺，提供关键环境和 维护和使用各种动物模型所需的专用设备。VS的员工 确保所有动物得到适当的临床护理，并为研究人员执行技术程序。 多学科病理学实验室LCP及其基因工程动物(GEA)表型鉴定 服务通过提供临床和解剖学方面的支持来支持单个实验室的研究和PARC的项目 GEA的病理服务和广泛的表型特征。

The Center of Comparative Medicine and Pathology (CCMP) supports animal model development and use through its Research Animal Resource Center (RARC) and Laboratory of Comparative Pathology (LCP). At MSKCC, animal models are used in basic and applied investigational studies as well as for training of both clinical and research staff. Animals are employed in diverse areas including the development of new methods for diagnosis and treatment of cancer as well as the elucidation of the basic biological mechanisms resulting in neoplasia. CCMP's professional and paraprofesslonal staff (131 FTE) serve as a consultative and technical resource for MSKCC investigators on all matters related to animal research. RARC is comprised of four sections: 1) Biosecurity; 2) Education and Quality Assurance (EQA); 3) Husbandry and Operations (H&O); and 4) Veterinary Services (VS). RARC provides housing for and humane care to over 170,000 animals daily, utilized by 140 investigators. PARC's oversight of MSKCC's AAALAC-accredited, centrally managed, animal care program ensures the efficient use of available space and staff resources and allows for close professional monitoring of the animal research program. Biosecurity ensures that MSKCC's rodent colonies remain pathogen free by routinely surveying colony health and quarantining incoming rodents from vendors. EQA administers an extensive educational program which provides training to animal care and research staff via didactic and hands-on sessions, web based tutorials as well as written instructional materials. PARC's H&O section operates three specialized state-of-the-art facilities encompassing over 80,700 net square feet of space which provide critical environments and the specialized equipment necessary for the maintenance and use of a variety of animal models. VS's staff ensure that all animals' receive appropriate clinical care and perform technical procedures for research staff. The LCP, a multi-disciplinary pathology laboratory and its Genetically Engineered Animal (GEA) Phenotyping Service supports individual laboratory's research and PARC's programs by providing clinical and anatomic pathology services and extensive phenotypic profiles of GEA.