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RARC- RESEARCH ANIMAL RESOURCE CENTER

RARC-研究动物资源中心

基本信息

批准号：
8602880
负责人：
NEIL SCOTT LIPMAN
金额：
$ 244.93万
依托单位：
SLOAN-KETTERING INST CAN RESEARCH
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-01-20 至 2013-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8602880
关键词：
Accreditation Analgesics Anatomy Anesthesia procedures Anesthetic Gases Anesthetics Animal Euthanasia Animal Experimentation Animal Model Animal Sources Animal Welfare Act Animals Applied Research Area Autopsy Basic Science Beds Biocompatible Materials Biological Body Fluids Cancer Center Support Grant Canis familiaris Caring Clinical Comparative Pathology Consultations Containment Decontamination Development Diagnosis Diagnostic Procedure Diagnostics Research Diet Disease Education Effectiveness Ensure Environment Equipment Evaluation Exclusion Exercise Fluoroscope Genetically Engineered Mouse Glass Hazardous Chemicals Health Health Services Health Status Housing Human IACUC Image Immunocompromised Host Individual Infectious Agent International Investigation Isoflurane Laboratories Laboratory Animal Medicine Laboratory Animals Laboratory Research Maintenance Malignant Neoplasms Medical center Memorial Sloan-Kettering Cancer Center Methods Microscope Modality Monitor Mycoplasma Neoplasms New York Operating Rooms Operative Surgical Procedures Oral Oryctolagus cuniculus Parasites Pathology Pharmacy facility Phenotype Physiology Play Policies Postoperative Period Preparation Procedures Process Quality Control Quarantine Radioisotopes Recovery Room Regulation Research Research Activity Research Personnel Research Support Resources Rodent Role Safety Sampling Science Sentinel Serologic tests Services Slice Source Sterilization Surgeon Surveys System Techniques Tissues Toxic effect Training United States National Institutes of Health United States Public Health Service Universities Vaporizer Vendor Veterinarians Virus Water Writing Xenograft procedure animal care animal facility animal model development animal resource arm cancer therapy clinical care computerized digital feeding feral guide for the care and use of laboratory animals imaging modality improved in vivo instrument medical schools microbial nonhuman primate nutrition operation pathogen programs quality assurance square foot treatment planning tumor wasting

项目摘要

The Research Animal Resource Center (RARC) supports animal model development and use at MSKCC. At MSKCC, animal models are used in basic and applied investigational studies. Animals are employed in diverse areas including the development of new methods for diagnosis and treatment of cancer, and the elucidation of the basic biological mechanisms resulting in neoplasia. RARC is comprised of six sections: 1.) Husbandry and Operations; 2.) Animal Health Service (AHS); 3.) Education and Quality Assurance (EQA); 4.) Laboratory of Comparative Pathology (LCP); 5.) Genetically Engineered Mouse Phenotyping (GEM) Core; and, 6.) Administration and Finance, which provide housing for and humane care to over 90,000 animals daily utilized by 99 research laboratories. RARC's oversight of MSKCC's AAALACaccredited, centrally managed, animal care and use program ensures the efficient use of available space and staff resources and allows for close professional monitoring of the in vivo (animal) research program. RARC operates three specialized state-of-the-art facilities encompassing over 66,000 net square feet of space which provide critical environments and the specialized equipment necessary for the maintenance and use of a variety of animal models. RARC's board-certified professional and paraprofessional staff (83 FTE) serve as a consultative and technical resource for MSKCC investigators on all matters related to animal research, The AHS's veterinary and veterinary technical staff ensure that all animals' receive appropriate clinical care and ensure that MSKCC's rodent colonies remain pathogen free by routinely surveying colony health and quarantining all incoming rodents from atypical vendors. Additionally, AHS staff perform technical procedures for research staff in support of their animal research programs. The LCP and the GEM core provide clinical and anatomic pathology services which ensure the health of the resident colonies but are also used extensively in support of individual laboratory's research programs. RARC's extensive educational program is administered by the EQA section which provides training to research staff via didactic and hands-on sessions as well as various written instructional materials. RARC also provides post-graduate training to veterinarians in both Laboratory Animal Medicine and Science, and Comparative Pathology in conjunction with the Weil Medical College of Cornell University, the Rockefeller University, and the Animal Medical Center.

研究动物资源中心（RARC）支持MSKCC的动物模型开发和使用。在MSKCC，动物模型用于基础和应用研究。动物被用于不同的领域，包括诊断和治疗癌症的新方法的开发，以及阐明导致瘤形成的基本生物学机制。RARC由六个部分组成： 1.）的人。饲养和操作; 2.）动物卫生服务（AHS）; 3.）教育和质量保证 (EQA)（4）比较病理学实验室（LCP）; 5.）基因工程小鼠表型分析 (GEM)核心;以及，6.）行政和财政，为超过1000万人提供住房和人道主义照顾。 99个研究实验室每天使用90，000只动物。RARC对MSKCC的AAALA认证的监督，集中管理的动物护理和使用计划确保有效利用可用空间和工作人员资源，并允许密切的专业监测体内（动物）研究计划。 RARC运营着三个专业的最先进的设施，占地面积超过66，000平方英尺，提供关键环境和维护所需的专用设备的空间以及使用多种动物模型。RARC委员会认证的专业和准专业人员（83 FTE）作为MSKCC调查人员的咨询和技术资源，处理与以下事项有关的所有事项：动物研究，AHS的兽医和兽医技术人员确保所有动物的接收适当的临床护理，并确保MSKCC的啮齿动物群落保持无病原体，调查鼠群的健康状况，并阻止所有来自非典型供应商的啮齿动物进入。此外，AHS工作人员为研究人员执行技术程序，以支持他们的动物研究计划。lcp和 GEM核心提供临床和解剖病理学服务，确保居民的健康菌落，但也广泛用于支持个别实验室的研究计划。RARC的广泛的教育计划由EQA部门管理，为研究人员提供培训通过教学和实践课程以及各种书面教学材料。 RARC还为兽医提供实验动物医学和科学和比较病理学与康奈尔大学韦尔医学院，洛克菲勒大学和动物医疗中心。