Heart Failure Clinical Research Network

描述(由申请人提供)： 拟议的心力衰竭区域临床中心(HF-RCC)应用程序提供了接触执业医生的独特机会，以及支持心力衰竭研究和教育的农村和少数族裔外展。该网络是由莫尔豪斯医学院社区医生网络(CRN)开创的学术-社区医生合作伙伴关系，旨在促进基于临床研究和实践的质量改进。该网络允许在社区实践层面无缝集成NIH支持的临床协议。HF RCC建立在这种模式的基础上，将亚特兰大北部最大的心脏病小组诊所与亚特兰大南部及周边农村社区最大和最古老的两家少数族裔拥有的最大和最古老的心脏病诊所结合在一起，亚特兰大北部以尖端实践和研究闻名。该网络非同寻常的地理覆盖面，其社会经济和种族多样性从心力衰竭注册数据库中可见一斑，该数据库的摘要包含在本申请中。最后，与圣约瑟夫医院和格雷迪医院的合作为影响心血管护理和健康差距提供了前所未有的机会和信誉，这两家大型三级护理中心分别以屡获殊荣的心血管护理和向未得到充分服务的人提供出色的护理而闻名全国。MSM的长期使命是促进对所有人的公平关怀，这是推动该网络的最终引擎和激情。事实上，参与的诊所和医院将这一承诺作为他们对社区医生网络感兴趣的一个关键激励因素。我们基于我们在招聘和留住难以接触到的患者群体方面的经验和专业知识，提出了一个基础设施。这两个项目为充分利用该网络的智力和基础设施能力提供了机会。这两个项目都利用了我们RCC中心力衰竭患者的数量以及研究人员的专业知识。项目一吸引了我们对高血压性心脏病和心力衰竭重塑的研究兴趣，也利用了我们小组对 NO参与心脏和血管重塑。第二个项目主要基于我们的专业知识 合作者，Nicholas Chronos，医学博士，在临床前和早期临床试验中进行基于细胞的治疗。拟议的临床技能发展核心整合了现有的临床培训资源，如 MSM临床研究项目成功的理学硕士和被追捧的心血管 圣约瑟夫研究所的研究培训计划。总而言之，我们提出了一个非常独特的应用程序，它应该作为未来合作研究网络的典范，寻求积极参与和整合社区实践，这是NIH地图倡议的关键目标。(摘要结束)

DESCRIPTION (provided by applicant): The proposed Heart Failure Regional Clinical Center (HF-RCC) application provides a unique opportunity to access practicing physicians as well as rural and minority outreach to support heart failure research and education. The network is an academic - community physicians partnership pioneered by the Morehouse School of Medicine Community Physicians' Network (CRN), to promote clinical research and practice based quality improvement. The network allows seamless integration of NIH supported clinical protocols at the community practice level. The HF RCC builds up on this model by bringing together the largest Cardiology group practice, in North Atlanta, known in the southeast USA for leading edge practice and research with 2 of the largest and oldest minority owned Cardiology practices in the South Metro Atlanta and surrounding rural communities. The extraordinary geographic reach of the network, its socioeconomic and ethnic diversity is evident from the Heart Failure Registry database, a summary of which is included with this application. Finally, the affiliations with St. Joseph's Hospital and Grady Hospital, large tertiary care centers, respectively known nationally for award winning cardiovascular care and outstanding care delivery to the underserved, provide unprecedented opportunity and credibility to impact cardiovascular care and health disparities. The longstanding mission of MSM to promote equitable care for all is the ultimate engine and passion that drives the network. Indeed participating practices and hospitals have cited this commitment as a key motivator for their interest in the Community Physicians' Network. We have proposed an infrastructure based on our experience and expertise in recruiting and retaining difficult to reach patient populations. The two projects provide an opportunity to fully exploit the intellectual and infrastructure capacity of the Network. Both projects capitalize on the size of the Heart Failure patient population in our RCC, as well as expertise of investigators. Project one draws upon our research interest in remodeling in hypertensive heart disease and heart failure, and also takes advantage of our group's interest in the role of NO in cardiac and vascular remodeling. The second project is largely based on the expertise of our collaborator, Nicholas Chronos, MD in cell based therapies in preclinical and early phase clinical trials. The proposed clinical skills development core integrates existing clinical training resource such as the successful Master of Science in Clinical Research Program at MSM and the sought after cardiovascular research training program at St. Joseph's Research Institute. In summary, we have proposed a very unique application which should serve as a model for future collaborative research networks that seek to actively engage and integrate community practices, a key stated goals of the NIH to map initiative. (End of Abstract)