ACE UNIT BODY COMPOSITION STUDY

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 缺乏身体活动与瘦体重和功能能力的加速损失有关。我们的初步数据表明，与卧床休息28天的年轻人相比，卧床休息10天的老年人腿部瘦体重减少了3倍。此外，在健康的年轻志愿者中，身体不活动和模拟压力（高皮质醇血症）的组合分解代谢损伤导致瘦肌肉质量的损失比单独不活动大300%。这些数据强调了身体无行为能力的住院老年人肌肉质量和功能能力灾难性丧失的可能性。本项目的具体目标是量化UTMB急性老年护理（ACE）部门住院期间老年患者人群所经历的肌肉损失程度。将在入院时和出院前（通常为3-6天）使用双能X线吸收测定法（DEXA）获得身体组成数据（肌肉和脂肪量）。这些描述性数据随后将用于支持NIH拨款申请，重点是有针对性的干预措施，以减少肌肉损失和改善功能恢复。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Physical inactivity is associated with the accelerated loss of lean body mass and functional capacity. Our preliminary data demonstrate a 3-fold greater loss of lean leg mass in older individuals during 10 days of bed rest, compared to a cohort of younger adults during 28 days of bed rest. Further, in healthy young volunteers, the combined catabolic insults of physical inactivity and simulated stress (hypercortisolemia) resulted in a 300% greater loss of lean muscle mass than inactivity alone. These data highlight the potential for catastrophic loss of muscle mass and functional capacity in physically incapacitated, hospitalized older adults. The specific goal of this project is to quantify the magnitude of muscle loss experienced by an elderly patient population during a period of inpatient care in the Acute Care for Elders (ACE) Unit at UTMB. Body composition data (muscle and fat mass) will be obtained on admission and prior to discharge (typically 3-6 day period) using dual energy x-ray absorptiometry (DEXA). These descriptive data will be subsequently used to support NIH grant submissions focusing on targeted interventions to reduce muscle loss and improve functional recovery.