BEEF INGESTION AND MUSCLE PROTEIN METABOLISM

牛肉摄入和肌肉蛋白质代谢

• 批准号: 7378745
• 负责人: Douglas Paddon-Jones
• 金额: $ 2.11万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7378745
• 关键词: BEEF; INGESTION; MUSCLE; PROTEIN; METABOLISM

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Many individuals lose muscle mass and strength as they get older. One of the factors that may contribute to this loss is changes in the diet. Specifically, elderly individuals may not eat sufficient dietary protein or the protein they do eat may not be as efficiently assimilated into muscle tissue. Previous studies have examined the effect of protein supplements and amino acids on protein synthesis and muscle growth, but there is a lack of data examining the effect of common sources of dietary protein (i.e., beef) on muscle protein synthesis. The goal of this study is to measure changes in plasma concentrations of amino acids and muscle protein synthesis in young and elderly individuals following ingestion of 4 oz of lean beef. We will study a total of 20 healthy male and female volunteers between the ages of 20 and 50 (young) and 60 and 85 (elderly). We will use established techniques including stable isotope tracer methodology, blood sampling and muscle biopsies to measure changes in plasma hormone and amino acid concentrations and skeletal muscle synthesis. This project will examine changes in muscle protein synthesis in response to a common source of dietary protein. This study will address a number of the mechanisms contributing to muscle loss during aging. In particular, this project will have direct implications for both the quality and quantity of protein ingested as part of a daily diet.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。许多人随着年龄的增长而失去肌肉质量和力量。可能导致这种损失的因素之一是饮食的变化。具体而言，老年人可能不会吃足够的饮食蛋白，或者他们吃的蛋白质可能不会有效地吸收到肌肉组织中。先前的研究已经检查了蛋白质补充剂和氨基酸对蛋白质合成和肌肉生长的影响，但是缺乏数据来研究常见饮食蛋白（即牛肉）对肌肉蛋白质合成的影响。 这项研究的目的是在摄入4盎司瘦牛肉后，测量年轻和老年人的血浆氨基酸和肌肉蛋白质合成的变化。 我们将研究20至50岁（年轻）和60和85岁（老年人）的20名健康男性和女性志愿者。我们将使用已建立的技术，包括稳定的同位素示踪方法，血液采样和肌肉活检来测量血浆激素和氨基酸浓度的变化以及骨骼肌合成。 该项目将检查肌肉蛋白质合成的变化，以响应饮食蛋白的常见来源。这项研究将解决导致衰老期间肌肉损失的许多机制。特别是，该项目将对摄入的蛋白质的质量和数量有直接影响，作为日常饮食的一部分。