BIOBEHAVIORAL MECHANISMS OF EMOTION IN HIV DISEASE

HIV 疾病中情绪的生物行为机制

• 批准号: 7950884
• 负责人: KIRK Warren BROWN
• 金额: $ 4.95万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-12-01 至 2009-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7950884
• 关键词: Alcohol consumption; Behavioral; Behavioral Mechanisms; Biological; Chronic; Chronic Disease; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Disease; Drug usage; Eating; Emotions; Food; Funding; Goals; Grant; HIV; Health; Health Status; Health behavior; Hydrocortisone; Institution; Mediating; Neurosecretory Systems; Persons; Physical activity; Process; Research; Research Personnel; Resources; Sampling; Smoke; Source; Symptoms; United States National Institutes of Health; Viral Load result; biobehavior; medication compliance; positive emotional state; sex risk; trait

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Positive emotion will relate inversely to cortisol levels, independent of the effects of negative emotion. 2: Positive emotion will relate to a positive health behavior profile such that it will directly relate to medication adherence, physical activity, and eating healthy foods and will inversely relate to smoking, alcohol use, drug use, and sexual risk behavior, independent of the effects of negative emotion. 3:. Positive emotion will inversely relate to viral load, HIV disease symptoms, and general symptoms and will directly relate to CD4+, independent of the effects of negative emotion. 4: The relation between positive emotion and health indicators will be partially mediated by cortisol levels and health behaviors, independent of the effects of negative emotion. 5: Negative emotions will relate to cortisol, health behaviors, and health indicators in the opposite direction from positive emotion, and the relation between negative emotion and health indicators will be partially mediated by cortisol and health behaviors. 6: Positive emotion will moderate the effects of negative emotion. The primary goal of the current study is to clarify the relation between positive emotion and health in persons with HIV disease and to evaluate whether both positive and negative emotions relate to health in persons with HIV disease via biological and behavioral mechanisms. This study will also seek to establish whether positive emotions relate to health independent of negative emotions or through interaction with negative emotion. Because the impact of emotions on health in chronic illness samples is likely to be a result of chronic, rather than momentary, behavioral practices and neuroendocrine processes, the current study will focus on the effects of trait, rather than state, emotion.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 积极的情绪将与皮质醇水平成反关系，而与负面情绪的影响无关。 2：积极的情绪将与积极的健康行为概况有关，以使其直接与药物依从性，体育锻炼和食用健康食品有关，并与吸烟，饮酒，吸毒和性风险行为成反比，与负面情绪的影响无关。 3：。积极的情绪将与病毒负荷，HIV疾病症状和一般症状成反比，并将与CD4+直接相关，而与负面情绪的影响无关。 4：积极情绪与健康指标之间的关系将由皮质醇水平和健康行为部分介导，而与负面情绪的影响无关。 5：负面情绪将与皮质醇，健康行为和健康指标相反，与积极情绪相反，负面情绪与健康指标之间的关系将由皮质醇和健康行为部分介导。 6：积极的情绪将减轻负面情绪的影响。 当前研究的主要目的是阐明艾滋病毒疾病患者积极情绪与健康之间的关系，并评估通过生物学和行为机制的阳性和负面情绪是否与艾滋病毒疾病患者的健康有关。这项研究还将寻求确定积极情绪是否与健康有关，而与负面情绪无关或与负面情绪的互动有关。由于情绪对慢性疾病样本中健康的影响可能是由于慢性而不是瞬时的行为实践和神经内分泌过程的结果，因此当前的研究将重点关注特质的影响，而不是状态。