BIOBEHAVIORAL MECHANISMS OF EMOTION IN HIV DISEASE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 积极情绪与皮质醇水平呈负相关，与负面情绪的影响无关。2：积极情绪将与积极的健康行为相关联，它将直接与服药依从性、体力活动和健康食品有关，与吸烟、酒精使用、药物使用和性风险行为负相关，与负面情绪的影响无关。3：。积极情绪与病毒载量、HIV疾病症状和一般症状呈负相关，与CD4+直接相关，与负面情绪的影响无关。4：积极情绪与健康指标之间的关系将通过皮质醇水平和健康行为部分中介，而与消极情绪的影响无关。5：消极情绪与皮质醇、健康行为、健康指标的关系与积极情绪相反，消极情绪与健康指标之间的关系部分通过皮质醇和健康行为起中介作用。积极情绪会缓和负面情绪的影响。 本研究的主要目的是阐明艾滋病患者的积极情绪与健康之间的关系，并评估积极情绪和消极情绪是否都通过生物学和行为机制与艾滋病患者的健康有关。这项研究还将试图确定积极情绪是否与健康有关，独立于负面情绪，还是通过与负面情绪的相互作用。因为在慢性病样本中，情绪对健康的影响很可能是慢性行为实践和神经内分泌过程的结果，所以目前的研究将专注于特质情绪的影响，而不是状态情绪的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Positive emotion will relate inversely to cortisol levels, independent of the effects of negative emotion. 2: Positive emotion will relate to a positive health behavior profile such that it will directly relate to medication adherence, physical activity, and eating healthy foods and will inversely relate to smoking, alcohol use, drug use, and sexual risk behavior, independent of the effects of negative emotion. 3:. Positive emotion will inversely relate to viral load, HIV disease symptoms, and general symptoms and will directly relate to CD4+, independent of the effects of negative emotion. 4: The relation between positive emotion and health indicators will be partially mediated by cortisol levels and health behaviors, independent of the effects of negative emotion. 5: Negative emotions will relate to cortisol, health behaviors, and health indicators in the opposite direction from positive emotion, and the relation between negative emotion and health indicators will be partially mediated by cortisol and health behaviors. 6: Positive emotion will moderate the effects of negative emotion. The primary goal of the current study is to clarify the relation between positive emotion and health in persons with HIV disease and to evaluate whether both positive and negative emotions relate to health in persons with HIV disease via biological and behavioral mechanisms. This study will also seek to establish whether positive emotions relate to health independent of negative emotions or through interaction with negative emotion. Because the impact of emotions on health in chronic illness samples is likely to be a result of chronic, rather than momentary, behavioral practices and neuroendocrine processes, the current study will focus on the effects of trait, rather than state, emotion.